Can Big Ben and the Steelers keep pace with the division-leading Bengals? They'll have to get past the Seahawks -- in Seattle. Will Brock Osweiler give the Broncos a fighting chance against the 10-0 Patriots?
All eyes are on the three unbeatens, especially the Patriots as Bill Belichick, Tom Brady and the 8-0 Pats head to New York to face the one team that's had their number in recent years. Could the Titans trip up the Panthers? Or the Texans ambush the Bengals?
The Ravens and Cardinals are heading in different directions. Baltimore, whose five losses have come by six points or less, still hopes to salvage its season. Arizona looks to bounce back from a tough loss and pad its NFC West lead. Here are five key stats to know when the two clash in Arizona.