Anthony Thomas (32) is mobbed after a 6-yard TD run in the second quarter.(AP)

"It's a good feeling, to be able to come out and within the game plan be able to score points and score points so quickly," said Drew Henson, who threw scoring passes of 27 and 33 passes to David Terrell in the second quarter, each time on Michigan's first play from scrimmage.

Anthony Thomas ran for 98 yards and three touchdowns, giving him 47 on his career and tying Tyrone Wheatley (1991-94) atop Michigan's career list. The Wolverines rolled up 282 yards on the ground.

"Everyone's been saying how explosive our offense could be, but that doesn't mean much," said Henson, who finished 14-for-18 for 233 yards with no interceptions. "It's up to us to go out and make plays."

Michigan (5-2, 3-1 Big Ten) did that and more, rolling up 562 net yards of offense for a 7.6 yards-per-play average. Indiana (2-4, 1-2) came into the contest averaging 38.4 points, but managed just 186 yards.

"We moved the ball but the early turnovers just killed us," Randle El said. "We put our defense in a real bad situation, and you just can't do that against a good team."

After losing 32-31 a week earlier at Purdue, the Wolverines emerged from Saturday's game tied for the conference lead with Purdue, Northwestern and Minnesota. Ohio State is a half-game behind at 2-1 after losing to Minnesota at home.

Randle El ran for 39 yards and completed 13 of 27 passes for 111 yards. He became the second player to run for 2,000 yards and pass for 5,000 in a career. Southwestern Louisiana's Brian Mitchell ran for 3,335 and threw for 5,447 from 1987-89.

The Hoosiers had little else to show for their efforts Saturday.

"This is one of those games you don't need to see the tape on," Indiana coach Cam Cameron said. "It was like it happened in slow motion, and we can't beat anybody when we play like that."

Michigan electrified the homecoming crowd of 110,909 with five touchdowns over a 9:01 span of the second quarter, starting when Marquise Walker blocked Ryan Hamre's punt, picked it up on the first bounce and raced 41 yards for a score with 11:12 left.

In addition to the quick TD strikes from Henson to Terrell, Thomas scored on a 6-yard run up the middle -- following a 75-yard pass from Henson to Walker -- and Chris Perry turned an off-tackle slant into a 22-yard score.

The 35 second-quarter points tied the school record for points set in 1982 against Northwestern and tied in 1992 against Houston. Michigan's 45 first-half points were second only to the 55 scored against Chicago in 1939 and matched in 1991 against Northwestern.

"The biggest thing about today is we hit a lot of big plays," Wolverines coach Lloyd Carr said. "We played a complete game and played real physical. In this conference and with what has happened in the past three weeks, you have to be ready for anything."

Thomas' 6-yard run gave the Wolverines a 52-0 lead with 10:08 left in the third period. The Wolverines' Hayden Epstein kicked two fourth-quarter field goals before Cameron replaced Randle El with junior Tommy Jones.

Michigan led 3-0 after Jeff Del Verne kicked a 40-yard field goal with 8:02 left in the first quarter. Howard's fourth interception of the season set up a Michigan drive capped by Thomas' 7-yard TD run with 3:08 left.