Michigan tight end Bill Seymour scores a touchdown during the second quarter Saturday.(AP)

"Now it's over. Got to move on."

Penn State feels the same way about itself, aware Thomas would be handful but ultimately finding few ways to stop him from helping send the visitors to their worst record in nearly 70 years.

"Anthony Thomas is a big, strong back," said Justin Kurpeikis, a senior Penn State defensive end. "He's tough, and we knew that he would be."

Drew Henson passed for 212 yards and two TDs to help Michigan (7-3, 5-2 Big Ten) send Penn State (4-7, 3-4) to its worst record since the Nittany Lions finished 2-5 in 1932.

Penn State had the chances but blew them, missing three first-half field goals and having another one blocked while committing five turnovers.

"We didn't give ourselves chances to win," said Joe Paterno, now with his first seven-loss season in his 35 years as the Nittany Lions' coach. "Our problems in converting come from a lack of confidence."

Said Kurpeikis: "We've had enough losing. It's tough, and the rest of the guys are at the ends of their ropes. This is a horrible loss, and there's nothing to feel good about."

Henson completed 14 of 29 passes but threw three interceptions, the first one snapping his streak of 193 tosses without a pick since October 1999 against Michigan State.

"I thought we were careless with the football," said Wolverines coach Lloyd Carr, his team part of a bottleneck atop the Big Ten, with Michigan to play next weekend at Ohio State.

Michigan topped 50 points in two of its previous three games, but struggled early Saturday before the offense warmed, eventually rolling up 444 yards to Penn State's 408.

The Wolverines trailed 3-0 after an opening quarter in which Henson misfired on his first seven passes for an offense that mustered just 35 yards - 32 by Thomas.

"We dominated the first quarter, and we had nothing to show for it," said running back Eric McCoo, who led Penn State with 102 yards on nine carries and caught six passes for 51 yards. "It came down to capitalizing on chances, and we didn't."

With the wind at his back the next quarter, Henson completed all five of his throws for 54 yards in an 11-play, 78-yard march capped by Thomas' 7-yard TD run.

After Ryan Primanti missed a 39-yard field goal -- one of his three in the first half -- Henson completions and Thomas runs of 15 and 19 yards led to Henson's tossing a 15-yard TD to Bill Seymour with 1:32 left in the half, upping the score to 14-3.

On the next play, an errant pass by Penn State's Rashard Casey was intercepted by James Whitley, who returned the ball 13 yards to the Penn State 17.

Four plays later, Hayden Epstein's 33-yard field goal upped Michigan's halftime margin to 17-3, and the Wolverines never looked back.

By intermission, Thomas had 104 yards on 18 carries.

Leading 20-3 by the fourth quarter, Michigan sealed it on Henson's 40-yard TD pass to B.J. Askew with 14:14 left.

Penn State countered five minutes with Matt Senneca's 50-yard scoring pass to wide receiver Bryant Johnson, but Michigan closed out scoring with a 1-yard TD run by Chris Perry with a second left.

Casey had 158 yards on 16-of-28 passing but had three interceptions for Penn State, which wraps up its season Saturday against visiting Michigan State.

"I wish we had 12 more games left," McCoo said. "I'm not happy with what's happening, and I think any guy on this team will say the same thing. We don't want to go out like this."