Wesley Wilson and Georgetown put an end to Hampton's surprise run in the NCAAs.(AP)

Kevin Braswell scored 15 points and Nat Burton had 13 as Georgetown beat Hampton 76-57 on Saturday, putting the 10th-seeded Hoyas (25-7) into the NCAA Tournament's round of 16 for the first time since 1996.

Fifteenth-seeded Hampton (25-7) wrecked office pools and became a sentimental favorite after shocking No. 2 Iowa State in the first round.

The Pirates knew they'd have Boise fans supporting them. The crowd even cheered when Hampton's band arrived six minutes before halftime of the contest between Georgia State and Maryland.

"We knew before the game that the crowd would be pulling for Hampton," Boumtje Boumtje said. "We talked about it and knew we needed to make a run early to quiet the crowd down."

It took longer than they'd hoped, but the Hoyas used their superior size and deeper bench to bury overachieving Hampton with a 26-6 run over the last 10 minutes of the first half.

"They wanted to do it so hard, they tried to do it as individuals and you can't do that against a team like Georgetown," said Hampton coach Steve Merfeld. "They were a pretty big team. We haven't faced that in the past."

The Hoyas advanced to meet Maryland in next week's West Regional semifinals in Anaheim, Calif. The Terrapins beat Georgia State 79-60.

Tarvis Williams, who hit the game-winner against Iowa State, scored 16 and blocked eight shots to lead Hampton, but he was smothered all day by Georgetown's centers, the 7-foot Boumtje Boumtje and 6-11 Wesley Wilson.

"Ruben established the tone early in the game, contesting Tarvis' shots," Georgetown coach Craig Esherick said. "That caused them to not give him the ball as much as they usually do."

LaSean Howard scored 14 and Marseilles Brown had 12 for the Pirates. Williams, Howard and Brown each got a long hug from Merfeld when they left in the closing minutes.

"What a great experience," Merfeld said. "There were a lot of tears in the locker room after the game, but they were tears of joy, not tears of sadness."

Hampton's upset of Iowa State was the fourth time a 15th-seeded team has beaten a No. 2 since the tournament expanded to 64 teams in 1985, but none of those first-round winners made it beyond the second round.

The Pirates tried to recapture their first-round magic, and with the Boise fans embracing the team, its jazzy band and cheerleaders, another upset didn't seem impossible.

"The fans were remarkable," Williams said. "We appreciated it, not just for us but for the fans at home. Even when we made slip-ups like before the half, the crowd was still with us. It was a great way to leave."

After the first round, Hampton was another word for upset.

In the second, Georgetown reminded everyone that Hampton is where the Hoyas found Allen Iverson, demonstrating the difference between a Big East school and the champions of the Mid-Eastern Athletic Conference.

"Georgetown is huge," Merfeld said. "Their massive size played a big part in wearing us down."

The Pavilion was rocking after Williams dunked on a feed from Brown with 10:53 remaining in the first half, tying it at 16-16. But the gym went silent after the Hoyas went inside to their big men to spark the big run.

"We were getting yelled at because we weren't getting the ball inside enough," Braswell said. "Once we spread the floor, things opened up and we turned up the defensive pressure."

Georgetown allowed only one field goal over that span, extending a 24-20 lead with a 14-0 run that featured 3-pointers by Braswell and 6-11 Lee Scruggs.

Burton, whose dramatic game-winner withstood an instant-replay review in the first-round win over Arkansas, got free underneath for two easy layups in the last minute and Georgetown led 42-22 at halftime.

The Pirates used a 9-4 run over the first 3:17 of the second half to make it interesting.

It was 50-35 after Williams hit two free throws, and the crowd got energized again. Just as quickly, the Hoyas put out the fire when Wilson sprinted down for a dunk that silenced the fans.

"We've played some of our best games this season when the crowd was against us," Boumtje Boumtje said. "It gives us incentive to play harder."

The Hoyas are in the NCAA Tournament for the first time since 1943 without John Thompson as coach.

He rode the team bus and then watched from the first row behind the bench after traveling from New Orleans, where on Friday he saw North Carolina's 70-48 win over Princeton. His son, John Thompson III, coaches the Tigers.

"It was important that coach Thompson was here," Esherick said. "He was at his son's game, and he should have been there. I'm glad he made it here."