MLB picks: Astros vs. Dodgers odds, best bets, predictions for July 5 from proven model
The Astros gave the Dodgers their worst home loss ever at Dodger Stadium on Friday. Check out the latest MLB predictions and props from the SportsLine Projection Model for Saturday's showdown

The Houston Astros kicked off their visit to the City of Angels in dominant fashion, blowing out the Los Angeles Dodgers 18-1 on Friday. That loss was actually the worst loss the Dodgers have ever had at Dodger Stadium, and the defending World Series champs will look to even the series up and exact some revenge when these two top contenders square off Saturday night at 7:15 p.m. ET on FOX.
If you're a sports fan interested in MLB betting and are looking for the latest Astros vs. Dodgers odds, MLB player props and MLB best bets today, make sure to see what the SportsLine Projection Model has to say about Saturday's contest.
This game is notable for many reasons, one of which being Shohei Ohtani making his fourth start of the 2025 season. He's pitched just four total innings so far, including two scoreless in his most recent start against the Kansas City Royals on June 28. Ohtani's strikeout prop at FanDuel Sportsbook is at 1.5, with the Over at -158 and the Under at +118.
The Astros will send out ace lefty Framber Valdez, who been fantastic this year with a 9-4 record and 2.72 ERA in 17 starts this year. The veteran southpaw is coming off back-to-back scoreless starts and posted a 1.74 ERA in 31 innings in June. Valdez's strikeout prop at FanDuel is at 5.5 (Over +124, Under -158), with the SportsLine Projection Model rating the Over as a 4-star recommendation thanks to a projection of 6.1 punchouts for this outing.
In addition to starting this game on the mound, Ohtani is also the favorite to homer at FanDuel at +265. He's third in MLB with 30 homers, behind Cal Raleigh's 35 and Aaron Judge's 32. Astros first baseman Christian Walker and third baseman Isaac Paredes are next up at +400 and +450, respectively, followed by Mookie Betts at +480. Jose Altuve, who homered twice on Friday, is +500, as is Teoscar Herandez for Los Angeles.
The Dodgers are -148 favorites (wager $148 to win $100) on the money line in the latest SportsLine consensus odds, while the Astros are +124 underdogs (wager $100 to win $124). The total currently resides at 8.5. You can find the model's latest projections, along with expert picks for Astros vs. Dodgers, at SportsLine.
Here are the SportsLine model's projections for Astros vs. Dodgers on Saturday.
HOUSTON ASTROS vs LOS ANGELES DODGERS | 7/5 | 7:15 p.m. ET
Money line
Pick: Astros +124
Houston wins in 43% of simulations, bringing value at these odds
Run line
Pick: Astros +1.5 (-174)
Houston covers in 66% of simulations, bringing value at these odds
Over/Under
Pick: Over 8.5 (-109)
The Over hits in 53.8% of simulations
Projected score: Dodgers 4.7, Astros 4.4