Getty Images

Southpaw Oleksandr Usyk will look to become the undisputed champion when he meets title-holder Anthony Joshua for the WBA (Super), IBF, WBO and IBO heavyweight titles on Saturday. The scheduled 12-round event will take place at Tottenham Hotspur Stadium in London. Usyk, 34, enters the bout having compiled an 18-0 career mark with 13 wins by knockout. Joshua, 31, is equally impressive having compiled a 24-1 record, including 22 wins by knockout.

The main card is slated to begin at 1 p.m. ET with the headliners expected to reach the ring by around 5:10 p.m. ET. Joshua is a -270 favorite (risk $270 to win $100), while Usyk is priced at +220 in the latest Joshua vs. Usyk odds from Caesars Sportsbook. The over-under for total rounds expected is set at 10.5. Before locking in any Usyk vs. Joshua picks, make sure you check out the boxing predictions from SportsLine combat sports analyst Brandon Wise.

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing analyst. His strong 2021 boxing record includes nailing the outcome of the much-anticipated fight between Paul and Askren. Wise told SportsLine members to expect an early knockout from Paul (-170), who delivered with a first-round overhand right against the hapless Askren (+150), who visibly stumbled after taking the referee's count. Anyone who has followed Wise's combat sports picks has seen massive returns. 

What's more, Wise also has been on point with his UFC predictions. He called Israel Adesanya by decision at +140 and Brandon Moreno to win outright at +190 at UFC 263 earlier this summer.

Now, with Saturday's showdown fast approaching, Wise has studied Joshua vs. Usyk from every angle, identified the best value in the boxing odds and released highly confident picks. You can head to SportsLine now to see all of his expert boxing picks.

Why you should back Joshua

Wise notes that 31-year-old Joshua has an impressive resume. In 25 total fights, he has 24 wins with 22 of those coming by knockout. He is a two-time world heavyweight title holder, having held the WBA (Super), IBF, WBO and IBO championships since December 2019. He also previously held those four between March 2018 and June 2019.

As an amateur, Joshua won a gold medal at the 2012 Olympics and was a silver medalist at super-heavyweight at the 2011 World Championships. The Ring ranks Joshua as the second-best active heavyweight. He has also been ranked by BoxRec as a top 10 heavyweight since 2014, and was No. 1 at the end of both 2016 and 2017.

Why you should back Usyk

Like Joshua, Usyk has had a lot of success throughout his career, including winning a gold medal as a heavyweight at the 2012 London Olympic Games. He also won a pair of medals at the world championships at heavyweight. He took bronze in 2009 at Milan and gold in 2011 at Baku, Azerbaijan. He began his professional career at cruiserweight in 2013.

He displayed his dominance immediately, and none of his first nine fights went the distance, winning each by knockout. He won his first WBO Inter-Continental cruiserweight title in 2014, and his first WBO cruiserweight title in 2016. When he defeated Murat Gassiev by unanimous decision in July 2018, he held the WBA (Super), WBC, IBF, WBO and The Ring cruiserweight titles. He moved up to the heavyweight division in October 2019 and, in his last fight, won a unanimous decision over Derek Chisora to win the WBO Inter-Continental heavyweight championship. 

How to make Joshua vs. Usyk picks

Wise likes the fight to go over 10.5 total rounds. He's also made the call on which fighter wins, and has a strong prop pick that returns 3-1. You can see all of Wise's expert picks and analysis at SportsLine.

Who wins Joshua vs. Usyk? And which prop is a must-back? Visit SportsLine now to see Brandon Wise's best bets for Saturday, all from the CBS combat sports specialist who was all over Jake Paul's win over Ben Askren earlier this year, and find out.