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Retired fighters known for their power return to the ring when boxing legend Evander Holyfield takes on ex-MMA star Vitor Belfort in a heavyweight boxing bout on Saturday. The fight is a replacement headliner after Belfort's scheduled bout with Oscar De La Hoya was scratched after De La Hoya tested positive for COVID-19. The main card is scheduled to begin at 7 p.m. ET with the headliners expected to enter the ring around 10 p.m. Holyfield is 44-10 with two draws and one no contest in his boxing career, while Belfort is 1-0. He is 26-14-1 in his career in the Octagon.

Both fighters enter at -115 (risk $115 to win $100) in the latest Holyfield vs. Belfort odds. Also on the main card is Anderson Silva at -1000 vs. Tito Ortiz (+600) at cruiserweight and Andy Vences (-104) vs. Jono Carroll (-126) at super featherweight. Before making any Holyfield vs. Belfort picks, make sure you check out the expert boxing predictions from SportsLine combat sports analyst Brandon Wise.

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing analyst. His strong 2021 boxing record includes nailing the outcome of the much-anticipated fight between Jake Paul and Ben Askren. Wise told SportsLine members to expect an early knockout from Paul (-170), who delivered with a first-round overhand right against the hapless Askren (+150), who visibly stumbled after taking the referee's count. 

Wise also has been on point with his UFC predictions. He called Israel Adesanya by decision at +140 and Brandon Moreno to win outright at +190 at UFC 263 earlier this summer. Anyone who has followed Wise's combat sports picks has seen massive returns.

Now, with Saturday's showdown fast approaching, Wise has studied Holyfield vs. Belfort from every angle, identified the best value in the boxing odds and released his highly confident Belfort vs. Holyfield picks. You can head to SportsLine now to see all of Wise's expert boxing picks.

Holyfield vs. Belfort preview

Wise notes that this is not an ideal fight due to the age of both combatants. Holyfield enters the ring under a month from his 59th birthday and has not been in the ring in more than a decade. That said, he has had a lot of success, reigning as the cruiserweight champion in the 1980s and at heavyweight in the 1990s. Holyfield is the only four-time world heavyweight champion.

After winning a bronze medal at the 1984 Summer Olympics, Holyfield made his professional debut in November of that year when he defeated Lionel Byarm by unanimous decision in a six-round bout. He went on to win his next 27 bouts before losing to Riddick Bowe in November 1992. After defeating Alex Stewart in his next fight, he regained the WBA and IBF heavyweight titles by winning by major decision over Bowe in a November 1993 rematch. Before announcing his retirement, Holyfield won six of his last nine fights with one no contest.

Belfort has just the one professional boxing fight under his belt, winning by knockout over Josemario Neves at 1:01 of the first round. He knocked his opponent down three times before finishing him off. Belfort has had a lot of success in the Octagon after beginning his career in October 1996, and is known for his explosive knockout power. Of his 26 MMA wins, 18 have been by knockout.

He won 10 of his first 12 matches, including winning the UFC 12 Heavyweight Tournament in February 1997. Belfort, however, has struggled since 2015, winning just two of his last seven bouts with one of those being a no contest.

How to make Holyfield vs. Belfort picks

Wise has made the call on which fighter wins and has locked in a strong pick on a method of victory prop. You can see all of his Holyfield vs. Belfort picks and analysis at SportsLine.

Who wins Holyfield vs. Belfort? And which prop is a must-back? Visit SportsLine now to see Brandon Wise's best bets for Saturday, all from the CBS combat sports specialist who was all over Jake Paul's win over Ben Askren earlier this year, and find out.