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The stakes have been raised for the trilogy fight Saturday night between Tyson Fury and Deontay Wilder, and both heavyweight sluggers are aware. They face off for the third time in a boxing main event at T-Mobile Arena in Las Vegas, with the main fight card set for 9 p.m. ET. Fury's WBC belt is at stake, but the winner will likely be considered the face of the division based on recent developments. Former three-title holder Anthony Joshua was upset by Oleksandr Usyk two weeks ago, opening the door for Fury or Wilder to have a leverage advantage for big-money fights and prestige for the foreseeable future. Wilder and Fury fought to a draw in their first meeting, followed by a seventh-round stoppage for Fury last February.

Caesars Sportsbook lists Fury as the -280 favorite (risk $280 to win $100) in the latest Fury vs. Wilder odds. Wilder is the +230 underdog, and the over-under for number of rounds the fight will go is set at 7.5. Before finalizing any Fury vs. Wilder picks, make sure you check out the predictions and betting advice from SportsLine combat analyst Brandon Wise.

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing analyst. His strong 2021 boxing record includes correctly calling victories for social-media-star-turned-boxing-phenom Jake Paul over former UFC fighters Ben Askren and Tyron Woodley. Moreover, the respected combat analyst also called Jamel Herring (+105) to defeat Carl Frampton (-125) for the WBO junior lightweight title in April. Anyone who has followed Wise's combat sports picks has seen massive returns. 

Now, with Saturday's mega-fight in sight, Wise has analyzed Fury vs. Wilder III from every angle and identified the best value in the latest boxing odds. You can see his confident money-line selection and other boxing picks at SportsLine.

Tyson Fury vs. Deontay Wilder III preview 

Upon hearing that Fury intends to use an even more assertive approach than he took in their rematch in February of last year, Wilder not only didn't flinch... he embraced it.

Despite getting knocked down twice, Wilder points out that he finished the fight on his feet and remains confident that Fury doesn't have the power to knock him out. As such, Wilder believes Fury is bound to get the worst of close exchanges and ultimately Wilder's power edge will be the difference.

Referee Kenny Bayless stepped in just as Wilder's corner team threw in the towel to indicate they wished the fight to be stopped. The decision led to the controversial firing of lead trainer Mark Breland, a former welterweight world champion who was praised in most circles for saving his fighter from further damage. Even so, Wilder told CBS Sports this week that he stands by the decision.

"It's definitely going to be a war, but I don't think Fury is going to be able to stand toe-to-toe with me," Wilder told CBS Sports on Thursday. "Even on my worst day, in the condition that I was in, he couldn't get me out of there. I finished the fight on my feet. I had a disloyal trainer throw in the towel when I had told him for many years before to never throw a towel in. You don't throw a towel in on a warrior, a king like myself. You let him fight to the end because I do have the equalizer."

How to make Tyson Fury vs. Deontay Wilder III picks

Wise likes the under 7.5 rounds in the latest Caesars Sportsbook boxing odds. He's also locked in a strong Wilder vs. Fury money-line pick. You can only see Wise's boxing picks and analysis at SportsLine

Who wins Tyson Fury vs. Deontay Wilder III? And which other picks should you be all over? Visit SportsLine now to see Brandon Wise's best bets for Saturday, all from the CBS combat sports specialist who has crushed his boxing picks in 2021, and find out.