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The Butler Bulldogs and the Xavier Musketeers are set to square off in a Big East Tournament matchup at 6 p.m. ET on Wednesday at Madison Square Garden. The Bulldogs are 9-14 overall, while Xavier is 13-7. The Bulldogs are 39-17-2 against the spread in their last 58 neutral-site games as an underdog. The Musketeers, meanwhile, are 5-2 against the spread in their last seven games following an against-the-spread loss.

The Musketeers are favored by six-points in the latest Xavier vs. Butler odds from William Hill Sportsbook, and the over-under is set at 133. Before entering any Butler vs. Xavier picks, you'll want to see the college basketball predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,600 for $100 players on its top-rated college basketball picks against the spread. It has also returned over $400 on all top-rated college basketball picks this season. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Xavier vs. Butler. You can head to SportsLine to see its picks. Here are several college basketball odds for Xavier vs. Butler:

  • Xavier vs. Butler spread: Xavier -6
  • Xavier vs. Butler over-under: 133 points
  • Xavier vs. Butler money line: Xavier -270, Butler +220
Featured Game | Xavier Musketeers vs. Butler Bulldogs

What you need to know about Xavier

The Musketeers came up short against the Marquette Golden Eagles this past Saturday, falling 66-59. Paul Scruggs led Xavier with 18 points and six rebounds. Zach Freemantle leads Xavier with 16.3 points and 9.0 rebounds per game, and Scruggs adds 5.8 assists per outing. 

Xavier went 2-0 against Butler this season, winning 68-55 on the road on Jan. 30 and then downing the Bulldogs 63-51 at home on Feb. 21. Xavier scores 75.1 points and allows 70.2 points per game this season.

What you need to know about Butler

The Bulldogs were on the wrong end of a 93-73 decision against Creighton on Saturday. Chuck Harris scored 29 points, grabbed six rebounds and dished four assists in the loss. Harris leads Butler with 12.8 points and 2.4 assists per game, while Bryce Nze adds 8.0 rebounds per outing. 

Butler scores 63.6 points per game, but is giving up 67.9 points per game this season. The Bulldogs have lost 12 of their last 18 meetings against Xavier. They're also 2-7 against the spread in their last nine games against the Musketeers.

How to make Butler vs. Xavier picks

The model has simulated Xavier vs. Butler 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Xavier vs. Butler? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to find out which side of the Butler vs. Xavier spread you need to jump on Wednesday, all from the model that has crushed its college basketball picks, and find out.