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The Clemson Tigers will take on the No. 22 St. Bonaventure Bonnies at 2:30 p.m. ET on Friday at TD Arena. The Bonnies are 3-0 and one of the preseason favorites in the A-10, while Clemson is 4-0 on the season and was picked to finish 11th in the preseason ACC media poll. St. Bonaventure is 2-1 against the spread this year. Clemson is 3-1 against the number.

This is a semifinal matchup of the 2021 Charleston Classic and the winner will take on the winner of Marquette vs. West Virginia in the final. The Bonnies are favored by three points in the latest Clemson vs. St. Bonaventure odds from Caesars Sportsbook, and the over-under is set at 123. Before making any St. Bonaventure vs. Clemson picks or predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. St. Bonaventure. You can head to SportsLine to see its picks. Here are several college basketball odds for St. Bonaventure vs. Clemson:

  • Clemson vs. St. Bonaventure spread: St. Bonaventure -3
  • Clemson vs. St. Bonaventure over-under: 123 points

What you need to know about Clemson

Everything went the Tigers' way against the Temple Owls on Thursday as they made off with a 75-48 victory. Guard Nick Honor was the offensive standout of the contest for Clemson, picking up 19 points. The Tigers shot 54.5 percent from the floor as a team in the win while limiting the Owls to just 35.8 percent shooting.

That sort of disparity in field-goal percentage has been a theme during Clemson's 4-0 start. The Tigers are shooting 51.7 percent from the floor as a team this season, while opponents are shooting just 37.7 percent. Brad Brownell's teams have always been defensively intense when they're at their best. But with four players averaging at least 12.0 points per game, Clemson has to feel like it has a shot to make some noise with a win on Friday.

What you need to know about St. Bonaventure

Meanwhile, even if it wasn't a dominant performance, St. Bonaventure beat the Boise State Broncos 67-61 on Thursday. Four players on St. Bonaventure scored in the double digits: guard Kyle Lofton (17), guard Jaren Holmes (14), guard Dominick Welch (12), and guard Jalen Adaway (10).

Mark Schmidt guided the Bonnies to the NCAA tournament for a third time last season and he's got an experienced club in his 15th season at the helm of the program. Lofton, Holmes, Welch and Adaway are all seniors with at least three years of experience in the program and they should all be champing at the bit for an opportunity to pick up a couple of resume-building wins to close out the Charleston Classic.

How to make St. Bonaventure vs. Clemson picks

The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Clemson vs. St. Bonaventure? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has crushed its college basketball picks, and find out.