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Duke vs. Lafayette odds, line: 2021 college basketball picks, Nov. 19 predictions from proven computer model

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The No. 7 Duke Blue Devils take on the Lafayette Leopards at 8 p.m. ET on Friday at Cameron Indoor Stadium. Duke head coach Mike Krzyzewski has started his farewell season off right, with an impressive 4-0 start. Meanwhile, Lafayette may have to wait a bit longer to get its first win of the season, after it has started 0-3. The Leopards are coming off of a 28-point loss to Pennsylvania on Tuesday. 

The Blue Devils are favored by 32.5 points in the latest Duke vs. Lafayette odds from Caesars Sportsbook, and the over-under is set at 147.5. Before entering any Lafayette vs. Duke picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,100 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Duke vs. Lafayette. You can head to SportsLine to see its picks. Here are several college basketball odds for Duke vs. Lafayette:

  • Duke vs. Lafayette spread: Duke -32.5
  • Duke vs. Lafayette over-under: 147.5 points

What you need to know about Duke

Everything went according to plan for Duke at home against the Gardner-Webb Bulldogs on Tuesday in a 92-52 victory. Duke got double-digit scores from six players: Guard Trevor Keels (18), forward Wendell Moore Jr. (14), center Mark Williams (13), forward Joey Baker (12), guard Jeremy Roach (10), and forward Paolo Banchero (10). Four of Keels' buckets in the game came on 3-pointers and the Blue Devils collectively made 45.5 percent of their 3s in the game.

Of the players that returned from last season's team, Moore was not only the most accomplished, but he's also taken the biggest step forward this year. Moore averaged 9.7 points and 4.8 rebounds last season in 27.6 minutes per game. Through the first four games of 2021-22, Moore has come away with 15 points and six rebounds with 5.3 assists per game.

What you need to know about Lafayette

Lafayette finished third in the Patriot League last season, but hasn't been able to carry that success into the start of this year. One of the biggest things working against the Leopards when it comes to their chances to cover the spread is free-throw shooting. Lafayette has made 88 percent of its free throws, but only takes eight of them per game on average. That's problematic because Duke has only given away nine to opponents per game in 2021-22.

Tyrone Perry has been the Leopards' top returning player from last season. He has averaged 14.7 points per game, and scored 25 with three rebounds and three assists against Cornell on November 16. Another player to keep an eye on is seven-footer Neal Quinn. The junior is averaging 11 points and 8.3 rebounds with 1.7 blocks per game.

How to make Lafayette vs. Duke picks

The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 70 percent of simulations. You can only see the pick at SportsLine.

Who wins Duke vs. Lafayette? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.

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