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Mike Krzyzewski and the Duke Blue Devils (29-6) battle Tom Izzo and the Michigan State Spartans (23-12) in the second round of the 2022 NCAA Tournament on Sunday afternoon. Duke, the No. 2 seed, had a compelling win in the first round, defeating Cal State Fullerton 78-61 on Friday. Michigan State, the No. 7 seed, pulled out a nail-biting win in the first round, outlasting Davidson 74-73.  

Tipoff is at 5:15 p.m. ET from Greenville. The Blue Devils are favored by 6.5-points in the latest Michigan State vs. Duke odds from Caesars Sportsbook, while the over-under for total points scored is 146. Before making any Duke vs. Michigan State picks, be sure to check out the college basketball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Duke vs. Michigan State and revealed its coveted picks and predictions for the NCAA Tournament 2022. You can head to SportsLine to see all of the model's college basketball picks. Here are several college basketball odds and trends for Michigan State vs. Duke:

  • Duke vs. Michigan State spread: Blue Devils -6.5
  • Duke vs. Michigan State over-under: 146 points
  • Duke vs. Michigan State money line: Spartans +240, Blue Devils -300
  • MSU: The Spartans are 5-0 ATS in their last five games overall
  • DUKE: The over is 6-1 in Duke's last seven games as a favorite

Why Duke can cover

Sophomore center Mark Williams provides Duke with some strength in the paint. Williams is averaging 11.1 points and 7.4 rebounds, while shooting 71 percent from the field. He has been a force on the defensive end, logging 2.8 blocks per game. The Virginia native has also recorded nine double-doubles. In Duke's first round win, Williams stuffed the stat sheet with 15 points, seven rebounds, five assists and five blocks. 

Freshman guard Trevor Keels gives the Blue Devils another legitimate scoring threat. Keels logs 11.7 points, 3.7 rebounds and three assists per game. The Maryland native provides Duke with instant offense off the bench. Keels has scored at least 13 points in 11 games. In the March 10 victory over Syracuse, he finished with 14 points, three rebounds and three assists. 

Why Michigan State can cover

Senior forward Gabe Brown is putting up a team-high 11.4 points with 3.9 rebounds per game. Brown also spaces the floor for Michigan State, shooting 37 percent from deep. The Michigan native logged at least 13 points in four of his last eight games. On March 12 against Purdue, Brown tallied 16 points, four rebounds and went 3-for-6 from 3-point range

Sophomore guard A.J. Hoggard is averaging seven points, 2.3 rebounds and 4.9 assists per game. Hoggard seems to have hit his groove at the right time. He's scored in double figures in four of his last 10 outings. In the first-round win over Davidson, the Pennsylvania native had 14 points, three rebounds and two assists. 

How to make Michigan State vs. Duke picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 147 points. The model also says one side of the spread hits 60 percent of the time. You can only see the model's pick at SportsLine.

So who wins Duke vs. Michigan State? And which side of the spread hits 60 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.