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Drew Timme, Chet Holmgren and the No. 1 Gonzaga Bulldogs (21-2) will face off with the Pepperdine Waves (7-20) in a West Coast Conference clash at 11 p.m. ET on Wednesday, Feb. 16 at Firestone Fieldhouse in Malibu, Calif.. Gonzaga is looking to close out its regular season on a high note and lock up one of the coveted No. 1 seeds in the upcoming NCAA Tournament, while Pepperdine enters this matchup looking to snap a two-game losing streak.

Gonzaga is favored by 31 points in the latest Pepperdine vs. Gonzaga odds from Caesars Sportsbook, and the over-under is set at 163.5. Before making any Gonzaga vs. Pepperdine picks, you need to see the college basketball predictions and betting advice from the red-hot computer simulation model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Pepperdine vs. Gonzaga, and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting lines for Pepperdine vs. Gonzaga:

  • Pepperdine vs. Gonzaga spread: Pepperdine +31
  • Pepperdine vs. Gonzaga over-under: 164 points

What you need to know about Pepperdine

Pepperdine was within striking distance but couldn't close the gap this past Saturday as they fell 91-85 to the Brigham Young Cougars. Despite the defeat, Pepperdine got a solid performance out of guard Houston Mallette, who shot 5-for-6 from downtown and finished with 31 points.

Pepperdine has lost 11 of its last 12 games and wasn't really competitive in several of the losses. The Waves will obviously have their hands full with Gonzaga, and will have to be much better than they have been all year on the defensive end. Pepperdine enters the game with the 12th most points allowed per game in college basketball, giving up 77.0 on average. The Waves are 10-16 against the spread in 2021-22.

What you need to know about Gonzaga

Meanwhile, while not quite a landslide, the matchup between Gonzaga and the Saint Mary's Gaels this past Saturday was still a pretty decisive one as Gonzaga wrapped it up with a 74-58 win at home. Forward Drew Timme was outstanding, recording 25 points and five assists along with eight rebounds.

Gonzaga's offensive attack ranks first in college basketball when it comes to points per game, scoring 90.0 on average. The Bulldogs have won 14 straight games after falling to Alabama on Dec. 4. Timme is once again an All-America candidate, averaging 17.7 points, 6.2 rebounds, and 2.6 assists per game. Freshman phenom Chet Holmgren isn't far behind with averages of 14.5 points, 9.3 rebounds, 3.3 blocks, and 2.0 assists per game. Gonzaga is 13-8-2 against the spread in 2021-22.

How to make Gonzaga vs. Pepperdine picks

The model has simulated Pepperdine vs. Gonzaga 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the model's Gonzaga vs. Pepperdine pick at SportsLine.

So who wins Gonzaga vs. Pepperdine? And which side of the spread hits almost 60 percent of the time? Visit SportsLine now to see which side of the Pepperdine vs. Gonzaga spread to jump on, all from the advanced model that is up almost $2,000 on its top-rated college basketball spread picks over the last five-plus years, and find out.