Josh Oduro added 17 points for for George Mason (6-5, 2-3 Atlantic 10 Conference). AJ Wilson had 15 points and 12 rebounds. Jordan Miller added 10 points and eight rebounds.
The Explorers' 26.1 field goal percentage represented the worst mark by a George Mason opponent this season.
Christian Ray had seven points and eight rebounds for La Salle (5-7, 2-3), which scored a season-low 19 points in the second half.
David Beatty, who was second on the Explorers in scoring coming into the matchup with nine points per game, failed to make a shot (0 of 5).
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