The Indiana Hoosiers and the Michigan State Spartans will face off in a Big Ten clash at noon ET on Saturday at Assembly Hall. The Hoosiers are 12-9 overall and 6-4 at home while MSU is 10-9 overall and 2-6 on the road. The Spartans have won six of the last 10 head-to-head matchups with the Hoosiers, but Indiana has covered the spread in six of those 10 contests. This season, Indiana has been the far more profitable team against the spread with a 12-9 record compared to an abysmal 4-15 mark for Michigan State.

The Hoosiers are favored by six points in the latest Indiana vs. Michigan State odds from William Hill Sportsbook and the over-under is set at 134.5. Before entering any Michigan State vs. Indiana picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Indiana vs. Michigan State. You can head to SportsLine to see its picks. Here are several college basketball odds for Michigan State vs. Indiana:

  • Indiana vs. Michigan State spread: Indiana -6
  • Indiana vs. Michigan State over-under: 134.5 points
Latest Odds: Indiana Hoosiers -6.5

What you need to know about Indiana

IU beat Minnesota 82-72 on Wednesday. IU got double-digit scores from five players: forward Trayce Jackson-Davis (20), guard Aljami Durham (16), forward Jerome Hunter (16), guard Armaan Franklin (11), and guard Rob Phinisee (10).

Jackson-Davis continues to be the driving force offensively for the Hoosiers. He's averaging 19.6 points and 9.4 rebounds per game in his sophomore season. However, getting outside scoring from Franklin (12.2 ppg) and Durham (11.4 ppg) will continue to be critical for Indiana as well.

What you need to know about Michigan State

Meanwhile, the Spartans came up short against the Purdue Boilermakers on Tuesday, falling 75-65. Guard Joshua Langford wasn't much of a difference maker for MSU, finishing with only nine points on 3-for-11 shooting in his 32 minutes on the court.

Michigan State lost the turnover battle 16-6 in that game and that's been a recurring theme for the Spartans, as they've lost or tied in the turnover category in nine consecutive games. Aaron Henry will have to take better care of the basketball while continuing to stuff the stat sheet. He's averaging 14.3 points, 5.5 rebounds and 3.5 assists per game this season.

How to make Indiana vs. Michigan State picks

The model has simulated Indiana vs. Michigan State 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in nearly 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Indiana vs. Michigan State? And which side of the spread hits almost 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.