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Kansas vs. Colorado odds, line: 2021 college basketball picks, Dec. 21 predictions from proven computer model

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The Colorado Buffaloes will take on the No. 7 Kansas Jayhawks at 9 p.m. ET on Tuesday at CU Events Center. Colorado is 9-3 overall and 7-1 at home, while the Jayhawks are 9-1 overall and 1-0 on the road. Kansas has won 19 of the last 20 meetings between these teams, including a 72-58 win in the most recent matchup (2019). 

The Jayhawks are favored by 10.5 points in the latest Colorado vs. Kansas odds from Caesars Sportsbook, while the over-under is set at 144. Before entering any Kansas vs. Colorado picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Colorado vs. Kansas. You can head to SportsLine to see its picks. Here are several college basketball odds for Kansas vs. Colorado:

  • Colorado vs. Kansas spread: Kansas -10.5
  • Colorado vs. Kansas over-under: 144 points

What you need to know about Colorado

Colorado brings a three-game winning streak into this contest after beating Cal State Bakersfield by 14 points on Saturday. The Buffaloes picked up wins over Eastern Washington and Milwaukee in their previous two games. They have already faced a pair of teams in the top 15 this season, losing to then-No. 13 Tennessee and then-No. 5 UCLA

The Buffaloes covered the spread in the loss to the Bruins, but they came up short against Tennessee. Those have been their only two games in the underdog role so far this season. Sophomore forward Jabari Walker leads Colorado with 13.3 points and 8.1 rebounds per game. 

What you need to know about Kansas

Kansas was able to grind out a victory over Stephen F. Austin this past Saturday, winning 80-72. Four Jayhawks scored in double digits in what was their fifth straight win. They relied heavily on Christian Braun, who had 21 points along with six boards. 

Kansas is led by one of the nation's premier players in senior guard Ochai Agbaji. He is scoring 22.0 points and is grabbing 4.2 rebounds per game in a lineup that features three double-digit scorers. Braun and former Arizona State guard Remy Martin are both in double figures as well. 

How to make Colorado vs. Kansas picks

The model is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 70 percent of simulations. You can only see the pick at SportsLine.

So who wins Kansas vs. Colorado? And which side covers over 70 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.

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