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The No. 8 Kansas Jayhawks look to stay hot when they take on the No. 14 Indiana Hoosiers in a key non-conference matchup in Lawrence, Kan., on Saturday. The Jayhawks (9-1), the defending Big 12 Conference regular season and tournament champions, have won three games in a row. The Hoosiers (8-2), who finished ninth in the Big Ten Conference at 9-11 and were 21-14 overall a year ago, have dropped two of three and are 1-1 on the road in 2022-23. This will be the 15th meeting between the schools with Indiana holding an 8-6 edge in the series.

The game from Allen Fieldhouse tips off at noon ET. Indiana is averaging 81.4 points per game, while Kansas averages 79.4. The Jayhawks are 5.5-point favorites in the latest Indiana vs. Kansas odds from Caesars Sportsbook, while the over/under for total points scored is set at 143. Before making any Kansas vs. Indiana picks, be sure to check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 6 of the 2022-23 college basketball season on a strong 17-10 roll on all-top rated CBB picks, returning almost $300. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Kansas vs. Indiana and just locked in its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Indiana vs. Kansas:

  • Indiana vs. Kansas spread: Kansas -5.5
  • Indiana vs. Kansas over/under: 143 points
  • Indiana vs. Kansas money line: Kansas -250, Indiana +205
  • IND: The Hoosiers are 5-0 against the spread in their last five games following a straight-up loss
  • KU: The Jayhawks are 4-1 ATS in their last five Saturday games
  • Indiana vs. Kansas picks: See picks at SportsLine

Why Kansas can cover

Senior guard Kevin McCullar Jr. is off to a strong start to the season, averaging 11.8 points, 7.2 rebounds and 2.1 assists per game. He is coming off a 21-point performance in the big win at Missouri last week. McCullar has a pair of double-doubles, scoring 10 points and grabbing 11 rebounds in a win over North Carolina State on Nov. 23. He also scored 17 points and pulled down 10 rebounds in a Dec. 1 win over Seton Hall.

Sophomore forward KJ Adams Jr. has started all 10 games for the Jayhawks this season, averaging 8.2 points, 4.5 rebounds and 2.4 assists. He has reached double-digit scoring in each of the last three games, including a 19-point effort at Missouri last Saturday. He had a solid freshman season, where he played in 37 games with one start as Kansas claimed the 2021-22 NCAA National Championship. He was also named to the 2022 Big 12 All-Freshman Team by the conference coaches.

Why Indiana can cover 

Senior forward Trayce Jackson-Davis has reached double-digit scoring in all nine games he has played in, including a season-high 30 points at Xavier on Nov. 18, in an 81-79 victory. The consensus Preseason All-American has registered three double-doubles and one triple-double. Against Nebraska on Dec. 7, he scored 12 points, grabbed 11 rebounds and dished out 10 assists. He had a monster game in Indiana's 77-65 win over No. 18 North Carolina on Nov. 30, scoring 21 points, grabbing 10 rebounds, dishing out four assists, and adding four blocks. In doing so, he became the only Division I player in the last 25 years to have 20-plus points, 10 or more rebounds, four or more assists, four or more blocks and no turnovers against an AP Top 25 opponent.

Senior guard Xavier Johnson has played in all 10 games for the Hoosiers and averages 10.9 points, 5.2 assists, 3.5 rebounds and 1.2 steals per game. In the loss to Arizona, Johnson recorded a double-double with 11 points and 11 assists. He scored a season-high 23 points in the win over Xavier. In his time with Indiana and at Pittsburgh, Johnson has amassed 1,674 career points.

How to make Indiana vs. Kansas picks

SportsLine's model is leaning Over on the total, projecting a combined 145 points. It has also generated an against-the-spread pick that cashes in more than 50% of simulations. You can only get the model's pick at SportsLine. 

So who wins Kansas vs. Indiana? And which side of the spread cashes in more than 50% of simulations? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up nearly $300 on its college basketball picks this season, and find out.