Jannson Williams had 11 points for Marshall (15-6, 9-5 Conference USA).
Jordan Shepherd scored a season-high 20 points for the 49ers (9-15, 5-11), whose losing streak reached eight games. Jahmir Young added 15 points and seven rebounds. Jared Garcia had 14 points and 11 rebounds.
The Thundering Herd improve to 2-0 against the 49ers this season. Marshall defeated Charlotte 75-67 on Friday.
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