One game separates No. 15 Louisville (18-3, 7-2 ACC) and No. 12 Virginia Tech (18-3, 7-2 ACC) from the top of the ACC standings, so their Monday night battle at 7 p.m. ET could be the difference-maker in the conference this season. The Hokies, who could have as few as seven scholarship players available, are listed as 4.5-point favorites in the latest Louisville vs. Virginia Tech odds, while the Over-Under for total points Vegas expects to be scored is set at 136 after late money came in on the under. If you're looking to lock in any Louisville vs. Virginia Tech picks of your own, be sure to see the college basketball predictions from the advanced computer model at SportsLine. 

This model, which simulates every game 10,000 times, has raked in the winnings for those following its picks. Over the past two years, the SportsLine Projection Model has returned over $5,200 to $100 players on its top-rated college basketball picks. It also entered Week 14 of the 2018-19 college basketball season on a blistering 90-58 run on top-rated college basketball picks against the spread. Anyone who has followed it is way up. 

Now, the model takes aim at Virginia Tech vs. Louisville. We can tell you the model is leaning Over, and it also has an extremely strong against-the-spread pick that hits in almost 70 percent of simulations, indicating that there's massive value on one side. You can only see that one at SportsLine.

The model has taken Virginia Tech's tough defensive mindset into account. Coach Buzz Williams was short-handed against NC State over the weekend, but a historic effort on that end of the court helped Virginia Tech get a 47-24 win over the Wolfpack. Yes, they held a Division I college basketball team to only 24 points.

Guard Justin Robinson (14.4 points per game, 5.4 assists per game) missed that game with a foot injury and will be out on Monday. But Nickeil Alexander-Walker (17.5 points per game) stepped up, and his ability to go off for 20 or more on any given night gives Tech enough of a presence on offense to back its strong defense. The Hokies are also 13-8 against the spread this season overall and 11-6 as a favorite.

But just because the Hokies are strong defensively doesn't mean they'll cover the Virginia Tech vs. Louisville spread.

The Cardinals took several hits in non-conference play as they took on a rugged schedule that included Tennessee, Michigan State, Marquette, Seton Hall, Indiana and Kentucky, among others. But they've looked strong in ACC play with wins over North Carolina and NC State already.

They'll test Tech's defense with an offense that has averaged almost 80 points per game facing a rough schedule. And Louisville is tough defensively as well, giving up just 68.1 points per game. With Virginia Tech star guard Justin Robinson (foot) among the players out for Monday's ACC battle, the Cardinals have a chance to keep it closer than four points.

Who wins Virginia Tech vs. Louisville? And which side of the spread hits in almost 70 percent of simulations? Visit SportsLine now to find out which side of the Louisville vs. Virginia Tech spread you should be all over, all from the model that has returned more than $5,200 to $100 players the past two years.