The Clemson Tigers host the Maryland Terrapins in an interesting non-conference matchup on Wednesday. Clemson and Maryland will face off as part of the ACC/Big Ten Challenge, and this is the second home game of the season for the Tigers. Clemson is off to a strong start, winning all three of its games and toppling both Purdue and Mississippi State. Maryland's early-season schedule has not been a gauntlet, but the Terrapins are 4-0 so far in 2020-21.

Tip-off is at 5 p.m. ET. William Hill Sportsbook lists the Tigers as two-point home favorites, while the over-under, or total number of points Vegas thinks will be scored, is 129 in the latest Maryland vs. Clemson odds. Before you make any Clemson vs. Maryland picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of almost $2,700 for $100 players on its top-rated college basketball picks against the spread. It's also off to a fast start in the 2020-21 season, going 5-1 on all its top-rated picks and returning over $400. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Maryland vs. Clemson in the ACC/Big Ten Challenge 2020. You can visit SportsLine now to see the picks. Here are the college basketball lines from William Hill and trends for Clemson vs. Maryland:

  • Maryland vs. Clemson spread: Clemson -2
  • Maryland vs. Clemson over-under: 129 points
  • Maryland vs. Clemson money line: Maryland +115; Clemson -135
  • MD: The Terrapins are 8-7 against the spread in the last 15 non-conference games
  • CLEM: The Tigers are 9-4 against the spread in the last 13 non-conference games

Why Maryland can cover

Maryland has been tremendous on offense this season, scoring 79 points or more in all four appearances. The Terrapins are elite in shooting efficiency, ranking in the top three nationally, and that is headlined by a 64.3 percent mark on two-point shots. That ranks in the top five of the country, and Maryland is also a top-25 three-point shooting team at 42.5 percent. On the offensive glass, the Terrapins have an advantage, grabbing 32.7 percent of their own missed shots this season. Defensive rebounding has also been a weakness for Clemson, with opponents of the Tigers posting a 37.4 percent offensive rebound rate. 

Defensively, Maryland is holding opponents to just 27.2 percent from three-point range, and Clemson is converting only 30.3 percent in its own right. The Terrapins can also rely on a top-25 national mark in free throw rate allowed, keeping their opponents away from the charity stripe and avoiding easy points against them.

Why Clemson can cover

Clemson is a solid two-way team, headlined by the presence of a potential first round NBA Draft pick in senior forward Aamir Simms. Because of Clemson's early-season dominance, Simms is only playing 18.7 minutes per game to this point, but he is averaging 12.0 points per game, shooting 56.5 percent and helping to anchor a quality defense. In fact, the Tigers are posting elite metrics defensively as a team, including a top-10 turnover rate, causing a giveaway on 31.4 percent of possessions. 

Clemson is also tremendous at making the opposition's shot attempts difficult, with the Tigers allowing only 29.2 percent shooting from three-point range and 37.4 percent shooting on two-point attempts. On the offensive side, the Tigers do most of their damage near the rim, which leads to a 54.7 percent mark on two-point attempts that is strongly above-average, both within the ACC and nationally.

How to make Maryland vs. Clemson picks

SportsLine's model is leaning over on the total, with both teams projected to have at least three players score eight points or more. The model also says one side of the spread hits in over 60 percent of simulations. You can only get the pick at SportsLine

So who wins Clemson vs. Maryland? And which side of the spread cashes in over 60 percent of simulations? Visit SportsLine now to see which side of the Maryland vs. Clemson spread to jump on, all from the advanced model that is up almost $2,700 on its top-rated college basketball spread picks over the past four-plus years, and find out.