The No. 12 Michigan State Spartans will take on the No. 18 Alabama Crimson Tide in a Thanksgiving matchup in the 2022 Phil Knight Invitational in Portland. The game will be the first meeting between the programs since 1998, when the Spartans took a 75-58 victory. This time around, the Spartans (3-1) will be without senior forward Malik Hall (foot) who was averaging 12 points and 5.3 rebounds for Michigan State this season. Meanwhile, Alabama (4-0) has had sensational play from a pair of freshmen in Brandon Miller and Rylan Griffen to start the year.

Tip-off is set for 10:30 p.m. ET from the Moda Center at the Rose Quarter. The Crimson Tide are favored by 5 points in the latest Michigan State vs. Alabama odds from Caesars Sportsbook, and the over/under is set at 145. Before entering any Alabama vs. Michigan State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of more than $1,400 for $100 players on its top-rated college basketball picks against the spread. 

Now, the model has set its sights on Michigan State vs. Alabama. You can head to SportsLine to see its picks. Here are several college basketball odds for Michigan State vs. Alabama:

  • Michigan State vs. Alabama spread: Alabama -5
  • Michigan State vs. Alabama over/under: 145 points
  • Michigan State vs. Alabama money line: Michigan State +160, Alabama -190
  • MSU: 2-2 against the spread this season
  • BAMA: Favored in all but one game this season (3-1 ATS)
  • Michigan State vs. Alabama picks: See picks here
Featured Game | Michigan State Spartans vs. Alabama Crimson Tide

What you need to know about Michigan State

Last week, Michigan State narrowly escaped with a win against the Villanova Wildcats, 73-71. The Spartans got double-digit scores from four players: Guards Tyson Walker (22) and  A.J. Hoggard (13), as well as forwards Joey Hauser (13) and Hall (12). Michigan State hit 51.9% of its attempts overall from the field, including an impressive 52% of their 3-pointers, with three apiece from Walker and Hauser.

Hall isn't the only player dealing with a foot injury, as sophomore guard Jaden Akins also could be carrying one into tonight's game. Akins scored nine points against Villanova off the bench, and if he is unavailable, the Spartans' lack of depth may become an issue. Offensively, the Spartans have been one of the country's best at creating scoring opportunities, and average 17.3 assists per game. Hoggard dishes out 8.3 per game to lead the team.

What you need to know about Alabama

Bama took its game at home last Friday with ease, in a 104-62 victory over the Jacksonville State Gamecocks. Miller put on a show with a 7-for-9 showing from beyond the arc and a season-high 28 points to go with eight boards. Nimari Burnett and Mark Sears each scored 18 points in the win as well. The Tide's 104 points were their most in a single game since the 95 they scored against Liberty on November 11.

Alabama is the top rebounding team in the nation, and average 56 per contest this season. Noah Clowney has been the Tide's top player on the glass, and pulls down 10.5 per game. Miller is right behind him with 9.8 per outing, while Charles Bediako grabs the most offensive boards, with four per appearance. The Spartans are the 110th team in the nation in defensive rebounds (27.5), but that could take a hit with some of the injuries they are nursing.

How to make Michigan State vs. Alabama picks

The model has simulated Michigan State vs. Alabama 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

Who wins Michigan State vs. Alabama? And which side of the spread hits well over 50% of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks, and find out.