A Big Ten battle is on tap between the Michigan State Spartans and the Purdue Boilermakers at 7 p.m. ET Tuesday at Mackey Arena. Purdue is 13-8 overall and 8-1 at home, while MSU is 10-8 overall and 2-5 on the road. Purdue has won six of the last nine meetings between the teams. 

The Boilermakers are favored by six points in the latest Purdue vs. Michigan State odds from William Hill Sportsbook, and the over-under is set at 136.5. Before entering any Michigan State vs. Purdue picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Purdue vs. Michigan State. You can head to SportsLine to see its picks. Here are several college basketball odds for Michigan State vs. Purdue:

  • Purdue vs. Michigan State spread: Purdue -6
  • Purdue vs. Michigan State over-under: 136.5 points
Latest Odds: Michigan State Spartans +5.5

What you need to know about Michigan State

The Spartans lost 88-58 against the Iowa Hawkeyes this past Saturday. Joey Hauser finished with only nine points on 4-for-12 shooting in his 25 minutes on the court. Michigan State has lost five of its past seven games. The Spartans are in danger of missing the NCAA Tournament for the first time since 1997. 

The loss to Iowa was the most lopsided in Tom Izzo's 16 years at the helm. Gabe Brown scored 15 points. Hauser leads the Spartans in rebounding at 6.8 per game. Foster Loyer (shoulder) and Rocket Watts (health and safety protocols) are questionable for Tuesday's game. 

What you need to know about Purdue

Meanwhile, Purdue lost 71-68 to the Minnesota Golden Gophers last Thursday. Trevion Williams dropped a double-double on 24 points and 10 boards. The Boilermakers have lost three of their past five games. They blew a five-point lead with two minutes remaining against the Golden Gophers. 

Eric Hunter Jr. had 14 points  vs. Minnesota. The Boilermakers only made two of 17 3-point attempts, missing 12 straight at one point. Purdue has held 10 straight opponents to 72 or fewer points.

How to make Michigan State vs. Purdue picks

The model has simulated Purdue vs. Michigan State 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Purdue vs. Michigan State? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Purdue vs. Michigan State spread to jump on Tuesday.