The Dons will face top seed and second-ranked Gonzaga in the semifinals on Monday.
Jimbo Lull had 16 points for San Francisco (22-11). Jamaree Bouyea added 11 points. Khalil Shabazz had six rebounds.
Pacific totaled 19 second-half points, a season low for the team.
Jahlil Tripp had 29 points and 14 rebounds for the Tigers (23-10). Gary Chivichyan added 12 points.
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