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The Mississippi State Bulldogs and the No. 19 Tennessee Volunteers are set to square off in an SEC matchup at 9 p.m. ET on Wednesday at Humphrey Coliseum. MSU is 14-7 overall and 12-1 at home, while the Volunteers are 16-6 overall and 3-4 on the road. The Volunteers have won two of the last three head-to-head matchups but the Bulldogs have covered the spread in two of those three games.

Both teams have been profitable against the spread this season, with Tennessee going 13-9 against the number while Mississippi State has gone 12-10. The Volunteers are favored by 1.5 points in the latest Mississippi State vs. Tennessee odds from Caesars Sportsbook, and the over-under is set at 135.5. Before entering any Tennessee vs. Mississippi State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Mississippi State vs. Tennessee. You can head to SportsLine to see its picks. Here are several college basketball odds for Tennessee vs. Mississippi State:

  • Mississippi State vs. Tennessee spread: Mississippi State +1.5
  • Mississippi State vs. Tennessee over-under: 135.5 points
Featured Game | Mississippi State Bulldogs vs. Tennessee Volunteers

What you need to know about Mississippi State

The Bulldogs came up short against the Arkansas Razorbacks this past Saturday, falling 63-55. Guard Iverson Molinar (19 points) was the top scorer for MSU. The Panamanian is averaging 18.2 points and 4.0 assists per game but he is shooting a career-low 27.6 percent from the 3-point line in his third year on campus.

Garrison Brooks also had a solid game in the loss, posting a double-double on 12 points and 11 rebounds. Unfortunately, Mississippi State shot just 35.3 percent from the floor as a team and only managed to generate five Arkansas turnovers. It will need to be more efficient offensively and more disruptive at the defensive end against a strong Tennessee squad.

What you need to know about Tennessee

Meanwhile, the Volunteers made easy work of the South Carolina Gamecocks this past Saturday and carried off an 81-57 win. Tennessee got double-digit scores from four players: guard Josiah-Jordan James (20), guard Zakai Zeigler (18), guard Santiago Vescovi (13), and guard Kennedy Chandler (11).

Rick Barnes' squad matched its season best by going 14-for-17 from the 3-point line in the win over the Gamecocks. Tennessee was also stout defensively, holding South Carolina to 31.5 percent shooting from the floor. The Volunteers have now held half of their 22 opponents this season to less than 40 percent shooting from the field.

How to make Tennessee vs. Mississippi State picks

The model has simulated Mississippi State vs. Tennessee 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Mississippi State vs. Tennessee? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.