Mosley shot 12 for 14 from the line.
Keaton Hervey had 11 points for Missouri State (6-1, 3-1 Missouri Valley Conference), which earned its fifth straight home victory. Gaige Prim added 10 points and seven rebounds.
Randy Miller Jr. had 17 points for the Sycamores (3-6, 0-4), who have now lost four games in a row. Tyreke Key added 13 points and 10 rebounds. Tre Williams had 10 points and three blocks.
Jake LaRavia, whose 14 points per game heading into the matchup led the Sycamores, shot only 14% in the game (1 of 7).
The Bears improve to 2-0 against the Sycamores for the season. Missouri State defeated Indiana State 84-74 on Saturday.
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