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The No. 16 Oklahoma Sooners and the No. 17 Oklahoma State Cowboys are set to square off Monday in a Big 12 matchup at 9 p.m. ET at Gallagher-Iba Arena. Oklahoma State is 16-6 overall and 9-3 at home, while the Sooners are 14-7 overall and 4-5 on the road. The teams met on Saturday and it was Oklahoma State that won 94-90 in overtime on the road. 

The home team is 6-2 against the spread in the last eight Oklahoma vs. Oklahoma State meetings. The latest Oklahoma State vs. Oklahoma odds from William Hill Sportsbook list the Sooners as 2.5-point favorites, and the over-under is set at 142.5. Before entering any Oklahoma vs. Oklahoma State picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,600 for $100 players on its top-rated college basketball picks against the spread. It has also returned over $500 on all top-rated college basketball picks this season. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oklahoma State vs. Oklahoma. You can head to SportsLine to see its picks. Here are several college basketball odds for Oklahoma vs. Oklahoma State:

  • Oklahoma State vs. Oklahoma spread: Oklahoma -2.5
  • Oklahoma State vs. Oklahoma over-under: 142.5 points
  • Oklahoma State vs. Oklahoma money line: Oklahoma -140, Oklahoma State +120
Featured Game | Oklahoma State Cowboys vs. Oklahoma Sooners

What you need to know about Oklahoma State

Cade Cunningham went off for a career-high 40 points and 11 rebounds in the win over the Sooners on Saturday as the Cowboys won their fourth straight overall. Cunningham, who likely be one of the top picks in the 2021 NBA Draft, leads Oklahoma State in scoring at 19.8 points per game. 

Isaac Likekele pulls down 6.9 rebounds and dishes 3.7 assists per outing. The Cowboys score 76.5 points and allow 71.4 points per game.

What you need to know about Oklahoma

The Sooners got 23 points from De'Vion Harmon in Saturday's loss to Oklahoma State. It was Oklahoma's second straight loss.

Austin Reaves leads Oklahoma with 17.5 points, 5.6 rebounds and 5.1 assists per game. The Sooners score 75.6 point per game, and allow 68.6 points defensively.

How to make Oklahoma State vs. Oklahoma picks

The model has simulated Oklahoma State vs. Oklahoma 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Oklahoma vs. Oklahoma State? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to find out which side of the Oklahoma State vs. Oklahoma spread you need to jump on Monday, all from the model that has crushed its college basketball picks, and find out.