The Purdue Boilermakers look to continue their dominance in season openers when they host the Milwaukee Panthers on Tuesday. Purdue has won 16 of its 17 openers under coach Matt Painter, including each of the last nine. The Boilermakers have outscored their opponents by an average of 28.2 points during their winning streak. Milwaukee began its 2022-23 campaign Monday with a 102-46 triumph over the Milwaukee School of Engineering.

Tip-off from Mackey Arena in West Lafayette, Ind. is set for 6:30 p.m. ET. The Boilermakers are 25-point favorites in the latest Purdue vs. Milwaukee odds from Caesars Sportsbook, while the over-under for total points scored is 144. Before making any Milwaukee vs. Purdue picks, be sure to check out the college basketball predictions and betting advice from the SportsLine Projection Model.

The model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated more than $1,200 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Purdue vs. Milwaukee and just locked in its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Milwaukee vs. Purdue:

  • Purdue vs. Milwaukee spread: Boilermakers -25
  • Purdue vs. Milwaukee over/under: 144 points 
  • PUR: The Boilermakers were 2-9-2 against the spread in their final 13 games last season 
  • MIL: The Panthers went 1-7 ATS in their last eight road contests of 2021-22 
  • Purdue vs. Milwaukee picks: See picks here

Why Purdue can cover

The Boilermakers have been highly successful in season openers no matter the coach, posting a 103-21 record in such contests over their history. But they have won by at least 25 points in 12 of Painter's triumphs, including a 96-67 victory against Bellarmine last season. Painter is closing in on a milestone as he needs 16 overall wins to become the fifth coach in Big Ten history to reach 400 for his career.

Purdue has won all 17 games against Horizon League opponents during Painter's tenure and 24 straight overall as it is 39-2 all-time versus those clubs. Zach Edey is back to lead the Boilermakers after averaging 14.4 points and 7.7 rebounds last season. The junior center had a strong showing in the team's last exhibition game, scoring 23 points on 8-of-9 shooting while recording seven boards, two assists and a pair of blocks in just 16 minutes.

Why Milwaukee can cover

The Panthers elected to go in a new direction after finishing last season with a 10-22 record. They fired coach Pat Baldwin and replaced him with Bart Lundy, who led Division II Queens University to a 30-4 record in 2021-22. Milwaukee also enters the campaign with an almost entirely different roster that includes sophomore guard Kentrell Pullian.

A transfer from Eastern New Mexico, Pullian was the 2022 Lone Star Conference Freshman of the Year after averaging a team-high 12 points and 5.2 rebounds for the Greyhounds. The Panthers also will be looking for a strong showing this season from Ahmad Rand, who spent 2021-22 at Oregon State. The senior forward averaged 5.3 points for the Beavers, hitting double figures four times - including a career-high 15 against Samford.

How to make Purdue vs. Milwaukee picks

SportsLine's model is leaning Under on the total. It also says one side of the spread hits more than 60% of the time. You can only get the model's pick at SportsLine.

So who wins Purdue vs. Milwaukee? And which side of the spread hits more than 60% of the time? Visit SportsLine now to see which side of the Milwaukee vs. Purdue spread to jump on, all from the advanced model that is up more than $1,200 on its top-rated college basketball spread picks over the last six years, and find out.