The Dons (16-5-3 West Coast Conference) led 27-22 and outscored San Diego 22-10 in the first nine-and-a-half minutes of the second and were never never challenged down the stretch.
San Francisco has won five of its last six.
Braun Hartfield led San Diego (8-15, 1-7) with 11 points. The Toreros were 16-of-54 (30.2%) - including 1 of 12 from 3-point range and missed nine of 20 attempts from the foul line.
San Diego has dropped back-to-back contests and seven of eight.
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