The UCLA Bruins and the Southern California Trojans are set to square off in a Pac-12 matchup at 4 p.m. ET on Saturday at Pauley Pavilion and the game will be broadcast live on CBS. The Bruins are 17-7 overall and 11-0 at home, while USC is 20-6 overall and 6-3 on the road. The bitter rivals have split their last 10 head-to-head meetings both straight up and against the spread.

However, USC has been the far more profitable team against the number this season, covering in 17 of 26 contests, while UCLA is 11-13 against the spread. The Trojans are favored by two points in the latest USC vs. UCLA odds from William Hill Sportsbook and the over-under is set at 135.5. Before entering any UCLA vs. USC picks, you'll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,600 for $100 players on its top-rated college basketball picks against the spread. It has also returned over $500 on all top-rated college basketball picks this season. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Southern Cal vs. UCLA. You can head to SportsLine to see its picks. Here are several college basketball odds for UCLA vs. Southern Cal:

  • Southern California vs. UCLA spread: USC -2
  • Southern California vs. UCLA over-under: 135.5 points
  • Southern California vs. UCLA money line: USC -140, UCLA +120

What you need to know about UCLA

UCLA came up short against the Oregon Ducks on Wednesday, falling 82-74. Guard Johnny Juzang had a rough night: he picked up four fouls and turned the ball over four times en route to a 3-for-12, six-point finish. Jules Bernard turned in 23 points on a 10-for-16 shooting night in the loss. 

Bernard is now averaging 10.0 points and 4.5 rebounds per game while Juzang leads the team, averaging 14.2 points per game. Tyger Campbell has also had a strong season and ranks second in the conference in assists, as he's averaging 5.7 per game.

What you need to know about USC

Meanwhile, everything came up roses for USC at home against the Stanford Cardinal on Wednesday as the team secured a 79-42 win. USC can attribute much of its success to guard Drew Peterson, who had 15 points and six assists along with nine boards.

The Trojans shot 52.5 percent from the floor in the win and dominated despite a somewhat pedestrian effort from super freshman Evan Mobley. The 7-footer had 10 points and eight rebounds, but he's averaged 16.2 points, 8.5 rebounds and 2.8 blocks per game, so USC will need him to turn in a bigger performance on Saturday to best their rivals.

How to make USC vs. UCLA picks

The model has simulated Southern California vs. UCLA 10,000 times and the results are in. It is leaning over on the total and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

Featured Game | UCLA Bruins vs. Southern California Trojans

So who wins Southern California vs. UCLA? And which side of the spread has all the value? Visit SportsLine right now to see which side of the UCLA vs. Southern California spread you need to jump on, all from the computer model that has crushed its college basketball picks.