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The No. 21 USC Trojans (25-6) and the Washington Huskies (17-14) are set to square off in a Pac-12 matchup at 11:30 p.m. ET on Thursday, March 10 at T-Mobile Arena. Washington knocked off Utah 82-70 in its Pac-12 Conference Tournament opener on Wednesday night, while USC will be looking to rebound from its 75-68 loss to UCLA in its regular season finale on March 5. 

USC is favored by 5.5 points in the latest USC vs. Washington odds from Caesars Sportsbook, and the over-under is set at 141.5. Before making any Washington vs. USC picks, you need to see the college basketball predictions and betting advice from the red-hot computer simulation model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,600 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on USC vs. Washington, and just locked in its picks and CBB predictions. You can head to SportsLine now to see the model's picks. Here are several college basketball odds and betting lines for USC vs. Washington:

  • USC vs. Washington spread: USC -5.5
  • USC vs. Washington over-under: 142 points

What you need to know about USC

USC came up short against the UCLA Bruins on Saturday, falling 75-68. USC's loss came about despite a quality game from forward Isaiah Mobley, who had 20 points in addition to eight boards.

USC beat Washington 79-69 back on Feb. 17. The Trojans are looking to snap a two-game losing streak in this matchup, after dropping consecutive games to No. 2 Arizona and No. 13 UCLA. Isaiah Mobley, a junior power forward, has been stellar for USC, averaging 14.6 points, 8.5 rebounds and 3.1 assists per game. The Trojans are 15-16 against the spread in 2021-22.

What you need to know about Washington

Meanwhile, the Huskies earned some postseason bragging rights after a successful outing on Wednesday. They took down the Utah Utes 82-70. Four players on Washington scored in the double digits: guard Terrell Brown Jr. (22), guard Jamal Bey (19), guard Cole Bajema (16), and forward Emmitt Matthews Jr. (10).

Washington excels at forcing its opponents into mistakes. The Huskies enter the matchup with 15.5 takeaways per game on average, good for 26th best in college basketball. Brown continues to be a dominant force for Washington, averaging 21.7 points, 4.2 assists and 4.1 rebounds per game. The Huskies are 18-13 against the spread in 2021-22.

How to make USC vs. Washington picks

The model has simulated USC vs. Washington 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the model's Washington vs. USC pick at SportsLine.

So who wins USC vs. Washington? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Washington vs. USC spread to jump on, all from the advanced model that is up almost $1,600 on its top-rated college basketball spread picks over the last five-plus years, and find out.