Wilkins hit 5 of 7 3-pointers in the game marked the Missouri Valley Conference opener for both teams.
Shanquan Hemphill had 16 points for Drake (10-0). Tremell Murphy added 10 points. Roman Penn had 10 points and seven assists.
Tre Williams had 13 points for the Sycamores (3-3, 0-1). Cooper Neese added 13 points. Tyreke Key had 10 points. Jake LaRavia had 9 points and 12 rebounds.
The two teams meet again on Monday.
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