Wilson's third block of the game moved him past George Evans to become George Mason's single-season blocks leader at 78.
Xavier Johnson had 11 points and seven rebounds for George Mason (14-10, 3-8 Atlantic 10 Conference), which snapped its four-game losing streak. Jordan Miller added 11 points, and Jamal Hartwell II had 10 points.
George Mason put the game away with a 16-0 run for a 58-41 lead midway through the second half.
De'Riante Jenkins had 16 points for the Rams (17-7, 7-4). Issac Vann added 13 points, and Nah'Shon Hyland had 11 points.
The Patriots leveled the season series against the Rams. VCU defeated George Mason 72-59 on Jan. 5. George Mason faces George Washington at home on Saturday. VCU matches up against Richmond on the road on Saturday.
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