There is a lot on the line when No. 7 Oklahoma State (10-1, 7-1 Big 12) faces No. 10 Oklahoma (10-1, 7-1) in the 2021 Bedlam Series matchup on Saturday night. The Sooners are trying to book their spot in the Big 12 title game and both teams are hoping to keep their College Football Playoff hopes alive. Oklahoma has won the last six meetings and 16 of the last 18 games between the two teams.

Kickoff is set for 7:30 p.m. ET. The Cowboys are four-point favorites in the latest Oklahoma vs. Oklahoma State odds at Caesars Sportsbook, while the total is 49.5. Before locking in any Oklahoma State vs. Oklahoma picks, be sure to see the Bedlam predictions and betting advice from SportsLine's proven model

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oklahoma State vs. Oklahoma and just locked in its Bedlam Series picks and prediction. You can head to SportsLine now to see the model's CFB picks. Here are several college football odds and betting lines for OU vs. Oklahoma:

  • Oklahoma vs. Oklahoma State spread: Oklahoma State -4
  • Oklahoma vs. Oklahoma State over-under: 49.5 points
  • Oklahoma vs. Oklahoma State money line: OU +160, OSU -190
Featured Game | Oklahoma State Cowboys vs. Oklahoma Sooners

What you need to know about Oklahoma State

Oklahoma State has only been favored once against Oklahoma since 2013, which shows how well the Cowboys are playing this season. They have already clinched their spot in the Big 12 championship game after shutting out Texas Tech last week. Oklahoma State has covered the spread in nine consecutive games heading into Bedlam.

The Cowboys have not only been covering spreads, but five of their six covers have come by a double-digit margin. Their defense has been the biggest story, ranked third in the FBS in yards allowed per game. Oklahoma State will be motivated to keep its playoff hopes alive on Saturday night.

What you need to know about Oklahoma

Meanwhile, the Iowa State Cyclones typically have all the answers at home, but on Saturday the Sooners proved too difficult a challenge. Oklahoma bagged a 28-21 victory. QB Caleb Williams and RB Kennedy Brooks were among the main playmakers for Oklahoma as the former passed for one TD and 87 yards on 18 attempts in addition to rushing for one TD and 67 yards and the latter picked up 115 yards on the ground on 17 carries. One of the most memorable plays of the game was Williams' 74-yard touchdown rush in the first quarter.

The Sooners have had a roller coaster of a season offensively, which is very uncharacteristic of a Lincoln Riley-coached team. Things won't get any easier against the elite-level defense of Oklahoma State, but there is no denying that Oklahoma has explosive playmakers all over the field. If the Sooners can get things going offensively early on, they will have a good shot at pulling off the road upset in this long-standing rivalry game. 

How to make Oklahoma vs. Oklahoma State picks

The model is leaning over on the point total, projecting the teams to combine for 53 points. It's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the model's Oklahoma State vs. Oklahoma pick at SportsLine.

So who wins Oklahoma State vs. Oklahoma? And which side of the spread hits in over 60 percent of simulations? Visit SportsLine now to see which side of the Oklahoma vs. Oklahoma State spread you need to jump on, all from the model that has crushed its college football picks, and find out.