Talented offenses meet up in the 2021 Fiesta Bowl when the No. 25 Oregon Ducks (4-2) and the No. 10 Iowa State Cyclones (8-3) clash on Saturday at State Farm Stadium in Glendale, Ariz. Sophomore quarterback Tyler Shough helped navigate Oregon to the 38th-best offense nationally, while quarterback Brock Purdy and running back Breece Hall guided Iowa State to a No. 31 rank nationally. Both units finished in the top 40 nationally in scoring offense as well.

Kickoff is set for 4 p.m. ET. The latest Iowa State vs. Oregon odds from William Hill Sportsbook list the Cyclones as 5.5-point favorites, up from opening at -3.5. The over-under is up 1.5 points to 58. Before making any Oregon vs. Iowa State picks, be sure to check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It enters bowl season a sizzling 56-36 on all top-rated picks, returning over $400. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Oregon in the Fiesta Bowl 2021. You can visit SportsLine now to see the picks. Here are the college football odds and betting trends for Oregon vs. Iowa State:

  • Oregon vs. Iowa State spread: Cyclones -5.5
  • Oregon vs. Iowa State over-under: 58
  • Oregon vs. Iowa State money line: Cyclones -230; Ducks +190
  • ORE: 3-3 against the spread this season
  • ISU: 7-3 against the spread this season

Why Oregon can cover

Oregon utilizes a balanced attack offensively that makes it tough to key on any area. The Ducks averaged 249.5 passing yards per game and ran for 180.2. They ranked inside the top 50 nationally in both categories.

It was the defense, however, that made the big plays in the Pac-12 title game against USC. The Ducks created three turnovers that helped set up short fields for the offense. The Ducks only had 243 yards of total offense in that game, but still came out on top. Oregon's run defense was also elite in that matchup as it gave up just 38 yards on 28 attempts by the Trojans.

Why Iowa State can cover

Few teams boast the talent in the backfield that Iowa State has. Purdy is a third-year starter who has completed at least 65 percent of his passes in every season. He threw for 2,594 yards, 18 touchdowns and nine interceptions this year. Despite playing fewer games this season, he managed to set a career high in rushing (343 yards) and added four scores on the ground.

Hall, meanwhile, should enter next season with Heisman buzz after he piled up 1,436 yards and 19 scores on the ground this year. The sophomore powered an Iowa State rushing attack that ranked third in the Big 12 (192 ypg). The Cyclones are stout defensively as well, ranking second in the Big 12 in total defense (343 ypg) this year. 

How to make Oregon vs. Iowa State picks

SportsLine's model is leaning under on the total, as Purdy and Shough are both held to fewer than 275 yards through the air. It also has generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the pick at SportsLine

So who wins Iowa State vs. Oregon? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the Oregon vs. Iowa State spread to back, all from the advanced model on a 56-36 run on its top-rated college football picks this season.