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At least 20 teams still have a realistic shot at making the 12 team College Football Playoff field, so the Week 10 college football schedule brings plenty of meaningful matchups. The No. 15 Boise State Broncos already handled San Diego State 56-24 on Friday night, covering as a 23.5-point favorite. Now there are two ranked matchups on Saturday as No. 3 Penn State (+3) hosts No. 4 Ohio State and No. 20 SMU (-7.5) hosts No. 18 Pittsburgh. 

Other Week 10 college football lines involving CFP contenders include No. 1 Oregon (-14.5) at Michigan (3:30 p.m. ET, CBS), No. 2 Georgia (-14.5) vs. Florida and Duke at No. 5 Miami (-21). Before locking in any Week 10 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. 

An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce's vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects. Bruce also enters the Week 10 college football schedule on a 26-12 roll (+1258) on his official SportsLine college football spread betting picks. 

Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 10 and revealed picks for each matchup. Head to SportsLine to see every pick.

Top college football predictions for Week 10

One of the top college football picks Marshall is recommending for Week 10: Marshall likes Florida (+14.5) to cover against No. 2 Georgia in a 3:30 p.m. ET matchup in Jacksonville on Saturday. Billy Napier remains on the hot seat for the Gators, but the pressure has been relieved a touch with three wins in their last four and the only loss coming in overtime at Tennessee. 

Georgia, meanwhile, saw its stock go flying up by winning at No. 1 Texas, but Marshall points out that the overall spread numbers on Georgia are not encouraging recently.

"Florida has covered four straight into November, while Georgia had dropped five in a row ATS before the Texas win," Marshall told SportsLine. "Georgia is only 7-13-1 ATS since last season." See which other picks to make here

How to make college football picks for Week 10

Marshall has evaluated every other matchup and he's found an alarming 21-9 trend you need to know this week. Get betting analysis for each matchup at SportsLine.

So what college football picks can you make with confidence, and what alarming trend do you need to know about? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.

Week 10 college football odds 

See full Week 10 college football picks, odds and predictions here.

Saturday, Nov. 2

Air Force at Army (-21.5, 41.5)

Duke at Miami (-21, 55)

Ole Miss at Arkansas (+7.5, 54)

Ohio State at Penn State (+3, 47.5)

Florida vs. Georgia (-14.5, 52.5)

Oregon at Michigan (+14.5, 44.5)

Indiana at Michigan State (+7.5, 53.5)

Louisville at Clemson (-10.5, 62.5)

Texas A&M at South Carolina (+3, 44)

Wisconsin at Iowa (-3, 41.5)

Kentucky at Tennessee (-17.5, 45.5)

Pittsburgh at SMU (-7.5, 56)