Alabama vs. Louisville: Prediction, pick, spread, odds, line, TV channel, live stream, watch online

For the third straight year, Alabama will be opening the season as the No. 1 team in the nation. The next chapter of the Nick Saban era begins Saturday night as the Crimson Tide pursue their third College Football Playoff title in four years. Their first challenge? A Louisville team that has been somewhat of an afterthought this offseason after losing one of the best players in the nation from a year ago.

While Alabama will be working with two star quarterbacks jockeying for the starting job, Louisville enters this high-profile opener flying under the radar with drastically lowered expectations. After all, star signal caller Lamar Jackson has moved to the NFL. The Cardinals were picked to finish fifth in the ACC's loaded Atlantic Division, but coach Bobby Petrino and his staff have high expectations Jackson's successor and think this group has a chance to surprise the experts.

Alabama-Louisville will be one of the last big-time games to get started on Saturday night, so let's not waste any time taking a look at what we expect to go down in the Sunshine State.

Viewing information

Date: Saturday, Sept. 1 | Time: 8:14 p.m. ET
Location: Camping World Stadium -- Orlando, Florida
ABC | Live stream: WatchESPN


Alabama: Saban is so tired of you asking about the quarterbacks, but the No. 1 story that will come from this game will be about the quarterbacks. How both Tua Tagovailoa and Jalen Hurts play, how much of the game both play, who plays first, who plays when the Tide are near the goal line -- all of it will be dissected and analyzed. In a game where Alabama is heavily favored, we're expecting to see both players a good bit, but the how and when is going to come under scrutiny as the quarterback competition continues on into the regular season.  

Louisville: For two years, Jackson was the prolific offensive talent in all of college football. Losing a talent like that is going to result in lowered expectations, but Jawon "Puma" Pass is hoping to prove that his time spent backing up Jackson has prepared him to maintain the level of success established during this Petrino Part Two/ACC era of Louisville football. The good news for Pass is that several of the top targets from last year are back, including 6-foot-4 senior Jaylen Smith and 6-foot-2 sophomore Dez Fitzpatrick, but it's going to be on the offensive line to give him enough time against Alabama's defense to connect with that talented group of receivers.  

Prediction, picks

Saban just doesn't lose these games. Alabama is a perfect 11-0 under Saban in season openers with a four-touchdown margin of victory (39.5 points per game to 11.5 points allowed). The Tide are also 4-0 under Saban against the ACC specifically in season openers, most recently beating Florida State 24-7 in Atlanta to start the 2017 season. This is a large spread for a matchup of Power Five teams but of the history points to Alabama cruising in this matchup. The Tide should win, but I think Louisville's wide receivers hit enough big plays for the Cardinals to cover the number. Pick: Louisville +25.5

Which teams should you back on the first full weekend of the college football season? Visit SportsLine now to see the projected final score for every single FBS matchup, all from the model that nailed its final seven picks of the 2017-18 season and has returned over $4,000 in profit to $100 bettors over the last three seasons.    

CBS Sports Writer

Chip Patterson has spent his young career covering college sports from the Old North State. He's been writing and talking about football and basketball for CBS Sports since 2010. You may have heard him... Full Bio

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