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The Alabama Crimson Tide will take on the Southern Miss Golden Eagles at 7:30 p.m. ET on Saturday at Bryant-Denny Stadium. The Crimson Tide are 3-0 overall and 1-0 at home, while Southern Miss is 1-2 overall and 0-1 on the road. Alabama has won 20 consecutive games at home, while the Golden Eagles have won just four of their last 12 games dating back to last season.

The Crimson Tide are favored by 45-points in the latest Alabama vs. Southern Miss odds from Caesars Sportsbook, and the over-under is set at 58.5. Before entering any Southern Miss vs. Alabama picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Alabama vs. Southern Miss. You can head to SportsLine to see its picks. Here are several college football odds for Alabama vs. USM:

  • Alabama vs. Southern Miss spread: Alabama -45
  • Alabama vs. Southern Miss over-under: 58.5 points

What you need to know about Alabama

Things were close when Alabama and the Florida Gators clashed last Saturday, but Alabama ultimately edged out the opposition 31-29. Alabama can attribute much of its success to RB Brian Robinson Jr., who punched in one rushing touchdown in addition to snatching one receiving TD, and QB Bryce Young, who passed for three TDs and 233 yards on 35 attempts.

The Crimson Tide are averaging 46 points per game this season, which ranks 11th in the country. Alabama also features one of the nation's stingiest defenses, giving up an average of 13.5 points per game this season. The Crimson Tide have won seven consecutive meetings against Southern Miss, but Alabama is just 2-8 against the spread in its last 10 games played in September. 

What you need to know about Southern Miss

Meanwhile, Southern Miss came up short against the Troy Trojans last Saturday, falling 21-9. Southern Miss' offense struggled mightily in the loss as quarterback Ty Keyes threw for just 152 yards and two interceptions. 

Despite suffering a setback in their last outing, the Golden Eagles may be catching Alabama at the right time. The Crimson Tide are coming off a hard-fought battle on the road against Florida and have a SEC showdown against the high-flying Ole Miss Rebels next week. If Alabama is looking ahead to next week's matchup, Southern Miss could easily stay within this large spread. 

How to make Alabama vs. Southern Miss picks

The model has simulated Alabama vs. Southern Miss 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in nearly 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Southern Miss vs. Alabama? And which side of the spread hits in nearly 60 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.