Both Appalachian State and Louisiana are 4-1 to begin the 2021 season. Both teams are also perfect in conference play with a single loss against an impressive opponent on the road. The Appalachian State Mountaineers lost by only two points on the road against Miami (FL), with the Louisiana Ragin' Cajuns losing the season opener on the road against Texas. On Tuesday, the programs will match up in a Sun Belt clash.

Kickoff is set for 7:30 p.m. ET. The latest Appalachian State vs. Louisiana odds from Caesars Sportsbook list the Mountaineers as 4.5-point favorites, while the over-under for total points is set at 57, up three points from the opening line. Before finalizing any Louisiana vs. Appalachian State picks, be sure to see the college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,800 for $100 players on its top-rated college football picks against the spread. It also enters Week 7 of the 2021 season on a 19-7 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Appalachian State vs. Louisiana and revealed its CFB picks and predictions. Visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Louisiana vs. Appalachian State:

  • Appalachian State vs. Louisiana spread: Appalachian State -4.5
  • Appalachian State vs. Louisiana over-under: 57 points
  • Appalachian State vs. Louisiana money line: Appalachian State -200; Louisiana +170
  • APLST: The Mountaineers are 3-2 against the spread this season
  • UL: The Ragin' Cajuns are 1-4 against the spread in 2021

Why Appalachian State can cover

Appalachian State has one of the best offenses in the Group of Five, and the Mountaineers have an impressive array of skill position talent. Veteran quarterback Chase Brice operates the controls effectively, throwing for nearly 1,400 yards this season with 8.9 yards per attempt. Brice has eight touchdown passes against just three interceptions, and he puts his running backs and wide receivers in strong positions. Appalachian State has two excellent running backs, with Nate Noel leading the team in rushing yards (511) and yards per carry (6.4) and Camerun Peoples racking up eight touchdown runs to go along with 353 yards on 5.3 yards per tote. 

On the outside, Corey Sutton leads the team with 32 catches for 473 yards and three touchdowns, with two more receivers, Thomas Hennigan and Malik Williams, generating more than 300 yards through the air in only five games. All told, the Mountaineers are averaging more than 480 total yards and 35 points per game, and they have been even better against non-Power Five opponents.

Why Louisiana can cover

Louisiana has done the little things very well this season, and that is at least partially responsible for the team's overall success. One example is the Ragin' Cajuns leading the Sun Belt in punting average, generating 45.8 yards per kick this season. In this matchup, that is a big edge, with Appalachian State's offense playing at a high level and the Mountaineers also struggling in the punting game with the third-worst mark in the Sun Belt at 39.2 yards per punt attempt. Louisiana is also balanced defensively, with six players generating at least two tackles for loss, and the Ragin' Cajuns have a strong havoc creation rate. 

On the offensive side, balance is also of great importance for Louisiana. The Ragin' Cajuns have three rushers with more than 230 yards out of the backfield, 12 pass-catchers with multiple receptions this season, and a quarterback in Levi Lewis that also has more than 100 rushing yards in 2021. Louisiana is also experienced in tight games, going 3-0 in games decided by single digits this season.

How to make Louisiana vs. Appalachian State picks

SportsLine's model is leaning under on the total, projecting 49 combined points. It also has generated an against the spread pick that hits in well over 60 percent of simulations. You can get the pick over at SportsLine.

So who wins Appalachian State vs. Louisiana? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the Louisiana vs. Appalachian State spread to back, all from the advanced model that is up almost $3,800 on its top-rated college football spread picks, and find out.