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Get ready for a Big 12 battle as the Baylor Bears and the Iowa State Cyclones face off at 3:30 p.m. ET on Saturday, September 25 at McLane Stadium. Baylor is 3-0 overall and 1-0 at home, while Iowa State is 2-1 overall and 1-0 on the road. The Bears have yet to face a true test, while the Cyclones' lone loss came against No. 5 Iowa.

The Cyclones are favored by 6.5 points in the latest Baylor vs. Iowa State odds from Caesars Sportsbook, and the over-under is set at 47.5. Before entering any Iowa State vs. Baylor picks, you'll want to see the college football predictions from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Baylor vs. Iowa State and just revealed its picks and analysis. You can head to SportsLine now to see its CFB picks. Here are several college football odds and betting lines for Baylor vs. Iowa State:

  • Baylor vs. Iowa State spread: Baylor +6.5
  • Baylor vs. Iowa State over-under: 48 points
  • Baylor vs. Iowa State moneyline: Iowa State -280, Baylor +230
Featured Game | Baylor Bears vs. Iowa State Cyclones

What you need to know about Baylor

The Bears ran circles around the Kansas Jayhawks on Saturday, and the extra yardage (576 yards vs. 166 yards) paid off. Baylor was fully in charge, breezing past Kansas 45-7 on the road. Baylor quarterback Gerry Bohanon was slinging it as he passed for two touchdowns and 269 yards on 23 attempts in addition to rushing for another touchdown and 33 yards. Near the top of the highlight reel was Bohanon's 69-yard TD bomb to WR R.J. Sneed in the third quarter.

The Bears will face a much tougher test on Saturday against an Iowa State defense that is among the best in the country. 

What you need to know about Iowa State

Iowa State bounced back from their disappointing loss to rival Iowa by bagging a 48-3 victory over UNLV last weekend. Iowa State's success was spearheaded by the efforts of quarterback Brock Purdy, who passed for three TDs and 288 yards, in addition to picking up 33 yards on the ground. Wide receiver Xavier Hutchinson caught ten passes for two TDs and 133 yards.

Iowa State is allowing opposing offenses to rack up only 192.7 total yards per game. 

How to make Baylor vs. Iowa State picks

The model has simulated Baylor vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning under on the point total, and it also says one side of the spread has all the value. You can only see the model's Iowa State vs. Baylor pick at SportsLine.

So who wins Baylor vs. Iowa State? And which side of the spread has all the value? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks, and find out.