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The No. 15 BYU Cougars will take on the South Florida Bulls at 10:15 p.m. ET on Saturday, September 25 at LaVell Edwards Stadium in Provo, Utah. BYU (3-0) owns two wins over ranked opponents (Utah and Arizona State) in 2021 and has a 2-1 record against the spread. South Florida (1-2) notched its first win of 2021 against FAMU last weekend and has a 1-2 record against the spread. 

The Cougars are favored by 23 points in the latest BYU vs. South Florida odds from Caesars Sportsbook, and the over-under is set at 52. Before locking in any South Florida vs. BYU picks, you need to check out the college football predictions and analysis from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on BYU vs. USF and just revealed its CFB picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for USF vs. BYU:

  • BYU vs. South Florida spread: BYU -23
  • BYU vs. South Florida over-under: 52 points
  • BYU vs. South Florida moneyline: South Florida +1100, BYU -2400
Featured Game | BYU Cougars vs. South Florida Bulls

What you need to know about BYU

The Cougars haven't been particularly dominant in any phase of the game, but the fact remains they are 3-0 and have beaten two ranked opponents to start the 2021 season. 

Quarterback Jaren Hall has been efficient, completing 51-of-85 passes for 561 yards, seven touchdowns, and two interceptions. He's also racked up 166 yards rushing. Defensively, BYU is allowing a respectable 397.3 total yards per game, but more importantly they're only giving up only 16.7 points per contest. 

What you need to know about South Florida

South Florida took out the frustrations of their early season struggles on the Florida A&M Rattlers on Saturday, posting an impressive 38-17 win. The Bulls have had issues on both sides of the ball in 2021, but the key to them keeping this game close will likely be how well their defense, which ranks among the worst in the country through three weeks, performs. 

How to make BYU vs. South Florida picks

The model has simulated BYU vs. South Florida 10,000 times and the results are in. We can tell you that the model is leaning under on the point total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the model's BYU vs. USF pick at SportsLine.

So who wins BYU vs. South Florida? And which side of the spread is hitting in over 60 percent of simulations? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks, and find out.