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The No. 13 BYU Cougars (9-2) will take on the USC Trojans (4-6) at 10:30 p.m. ET on Saturday, November 27 at United Airlines Field at the Los Angeles Memorial Coliseum. USC has lost two straight, but can still qualify for a bowl with wins in its final two games. BYU enters this matchup on a four-game winning streak.

BYU is favored by seven points in the latest USC vs. BYU odds from Caesars Sportsbook, and the over-under is set at 63.5. Before locking in any BYU vs. USC picks, be sure to check out the college football predictions and betting advice from the red-hot simulation model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on USC vs. BYU and just released its CFB picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for USC vs. BYU:

  • USC vs. BYU spread: USC +7
  • USC vs. BYU over-under: 64 points
  • USC vs. BYU moneyline: BYU -270, USC +220

What you need to know about USC

There was early excitement for USC after they claimed the game's first points on Saturday, but it was the UCLA Bruins who ended up claiming the real prize. USC ended up on the wrong side of a painful 62-33 walloping at UCLA's hands. QB Jaxson Dart had a pretty unremarkable game, throwing two interceptions.

The Trojans are in the midst of one of the more forgettable seasons in program history. As usual, the talent is there for USC, but things just haven't clicked. If for some reasons the Trojans come out and play inspired football, they are capable of playing with and beating BYU.

What you need to know about BYU

Meanwhile, BYU ran circles around the Georgia Southern Eagles on Saturday, and the extra yardage (508 yards vs. 268 yards) paid off. The Cougars took down Georgia Southern 34-17. The victory came about even with BYU handicapping themselves with 84 penalty yards. Their success was the result of a balanced attack that saw several players step up, but QB Jaren Hall led the charge as he passed for two TDs and 312 yards on 28 attempts.

BYU has an explosive offense and an opportunistic defense. The Cougars are well-coached and own a perfect 4-0 record against Pac-12 opponents in 2021. BYU is 5-6 against the spread in 2021.

How to make USC vs. BYU picks

The model has simulated USC vs. BYU 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the model's BYU vs. USC pick at SportsLine.

So who wins BYU vs. USC? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the USC vs. BYU spread you need to jump on, all from the model that has crushed its college football picks, and find out.