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The latest Caesars Sportsbook promo code CBS20X gives new users 20 100% profit boosts after wagering $1 or more, which can be unlocked during the Week 1 college football schedule. There are games throughout the weekend, headlined by three top-10 showdowns. The first one takes place at noon ET on Saturday when defending champion and No. 3-ranked Ohio State hosts No. 1 Texas. Ohio State is a slight 1-point favorite in that matchup, while the over/under for total points scored is 47.5.  

On Saturday night, No. 4 Clemson (-4) faces No. 9 LSU, while No. 10 Miami hosts No. 6 Notre Dame (-3) on Sunday night. Before locking in your Week 1 college football picks on your favorite betting sites like Caesars Sportsbook, you'll also want to be sure to check out the top college football betting picks from SportsLine's proven computer model. Claim the latest Caesars Sportsbook promo code here, where new users bet $1 and double their winnings on their next 20 bets: 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anybody following its college football betting picks on betting sites could have seen strong returns.

Best Week 1 college football picks: 

Combining the model's three picks into a Week 1 college football parlay at Caesars would result in a payout of +596 (risk $100 to win $596). Bet it at Caesars here:

Under 47.5 points in Ohio State vs. Texas (-110)

These teams combined for 42 points in their College Football Playoff semifinal matchup last season, and both starting quarterbacks from that game are no longer on the roster. Sophomore Arch Manning has made two career starts for Texas, while redshirt freshman Julian Sayin is making his first start for Ohio State. Texas is replacing four starters from its offensive line, and Ohio State has an All-American safety in Caleb Downs. The Longhorns have gone Under in nine of their last 12 games, and SportsLine's model has the Under cashing in 57% of simulations. 

LSU +4 vs. Clemson (-110)

LSU enters the season with fifth-year quarterback Garrett Nussmeier at the helm after he threw for 4,052 yards and 29 touchdowns last year. Head coach Brian Kelly was more active in the transfer portal this offseason than in previous years, bringing in one of the highest-rated classes in the country. Sophomore running back Caden Durham is back after rushing for 753 yards and six touchdowns last season, while wide receiver Aaron Anderson joins Kentucky transfer Barion Brown to provide some elite targets for Nussmeier. The model has LSU covering the spread 65% of the time in this matchup. 

Michigan -34.5 vs. New Mexico (-110)

Michigan is entering a new era with freshman quarterback Bryce Underwood, who is considered the top player in the current freshman class by many recruiting services. Underwood originally committed to LSU before flipping to Michigan. The Wolverines struggled due to poor quarterback play last year, so Underwood could fix most of their issues from the jump. Even so, they salvaged their season with a win over eventual national champion Ohio State and then beat Alabama in the ReliaQuest Bowl. The model has them cruising to a blowout win on Saturday night, covering the spread 65% of the time. 

Want more Week 1 college football picks?

You've seen the model's Week 1 college football best bets. Now, get against the spread, total and money-line picks for every Week 1 CFB game here, all from the model that's simulated every game 10,000 times. 

Also at SportsLine:

You can also see Week 1 college football picks from legendary college football handicapper Bruce Marshall. Visit SportsLine to see his best bets. SportsLine's Emory Hunt, who is 45-32 in his last 77 college football picks, has locked in his best bet for Oregon State vs. California right here.