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No. 8 Cincinnati will look to make a statement as it travels to take on Indiana on Saturday. The Bearcats are aiming for the College Football Playoff this season, and they have some big opportunities coming up. Notre Dame is up next on the schedule, but Cincinnati can also gain some national credibility by taking down a Big Ten opponent on the road in this matchup. Indiana dropped its opener to Iowa before knocking off Idaho last week. 

Kickoff is set for noon ET. Caesars Sportsbook list the Bearcats at 3.5-point road favorites. The over-under for total number of points is set at 50. Before locking in any Indiana vs. Cincinnati picks, be sure to see the college football predictions and betting advice from SportsLine's proven model

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Cincinnati vs. Indiana and revealed its picks and predictions. You can visit SportsLine now to see the model's picks. Here are several college football odds and betting trends for Indiana vs. Cincinnati:

  • Cincinnati vs. Indiana spread: Cincinnati -3.5
  • Cincinnati vs. Indiana over-under: 50 points
  • Cincinnati vs. Indiana money line: Cincinnati -170, Indiana +145
  • CIN: The Bearcats are 12-1 straight up in their last 13 games
  • IND: The Hoosiers are 9-2 against the spread in their last 11 games
Featured Game | Indiana Hoosiers vs. Cincinnati Bearcats

Why Cincinnati can cover

Cincinnati hasn't tasted defeat many times over the last few seasons and has looked like one of the country's most dominant teams in 2021. The Bearcats opened up the year with consecutive 35-point victories. They only gave up 21 points of the process. Indiana is better on offense than Cincinnati's previous opponents but doesn't have a great track record against ranked teams.

Desmond Ridder and Jerome Ford have combined for 10 touchdowns in two games, and the Hoosiers were outscored 34-6 against Iowa in their season opener. Indiana will have to go toe-to-toe with one of the nation's most consistent offenses to cover in this matchup.

Why Indiana can cover

Indiana was one of the best teams in the country against the spread last year. The Hoosiers went 7-1 against the number and won all three of their home games. Cincinnati is 1-1 against the spread this year despite a pair of 35-point victories. 

The Hoosiers were held to a measly six points against Iowa but bounced back with their explosive offense against Idaho the following week. Indiana racked up three passing touchdowns, three rushing touchdowns, and two scores on special teams. Indiana has averaged 33 points per game at home since 2019, and that scoring upside could help the underdogs cover in what's projected to be a lower-scoring game.

How to make Indiana vs. Cincinnati picks 

SportsLine's model is leaning under on the point total, projecting teams to combine for 39 points. The model also says one side of the spread hits well over 50 percent of the time. You can only see the pick at SportsLine

So who wins Cincinnati vs. Indiana? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.