The No. 5 Cincinnati Bearcats continue their pursuit of a College Football Playoff berth against a talented opponent on Saturday. The Bearcats welcome the SMU Mustangs to Nippert Stadium for an American Athletic Conference showdown. The Bearcats are 10-0 overall with a 6-0 mark in AAC play. SMU (8-2, 4-2), however, will be the first team with a winning record Cincinnati has seen since   Oct. 16, and the Bearcats have failed to cover in their last four games. 

Kickoff is set for 3:30 p.m. ET. Caesars Sportsbook lists the Bearcats as 10-point favorites in the latest Cincinnati vs. SMU odds. The over-under for total points is set at 65.5. Before locking in any SMU vs. Cincinnati picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Cincinnati vs. SMU and it just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for SMU vs. Cincinnati:

  • Cincinnati vs. SMU spread: Cincinnati -10
  • Cincinnati vs. SMU over-under: 65.5 points

What you need to know about Cincinnati

Offensively, quarterback Desmond Ridder is having a big year -- throwing for 2,425 yards, 22 touchdowns and just six interceptions. He's also the second-leading rusher with 279 yards and five scores. Running back Jerome Ford leads the way with 888 yards and 15 rushing TDs. 

The Bearcats have the best scoring defense in the AAC, giving up just 16.2 points per game. They ranked second in the AAC in total defense at 315.8 ypg, trailing only Houston (294.6 ypg). 

What you need to know about SMU

Meanwhile, SMU knocked off UCF by a 55-28 margin in its last outing. Among those leading the charge for the Mustangs was running back Tre Siggers, who punched in three rushing touchdowns.

Siggers and Ulysses Bentley IV both help keep defenses honest and allow for Dykes' offense to attack down the field. Tanner Mordecai has thrown for 3,264 yards and 37 touchdowns with just 10 interceptions but he'll have to be careful taking his shots against a Cincinnati defense that has 15 interceptions this season.

How to make SMU vs. Cincinnati picks

The model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the model's Cincinnati vs. SMU pick at SportsLine.

So who wins Cincinnati vs. SMU? And which side of the spread hits nearly 60 percent of the time? Visit SportsLine now to see which side of the spread you need to be all over, all from the model that has crushed its college football picks, and find out.