Clemson vs. Boston College odds, line: Picks, predictions with Trevor Lawrence out from model on 29-19 run
SportsLine's advanced computer model simulated Boston College vs. Clemson on Saturday 10,000 times.

Heisman front runner Trevor Lawrence will miss Clemson's matchup against the Boston College Eagles on Saturday after testing positive for COVID-19 earlier this week. Backup quarterback D.J. Uiagalelei is expected to start in Lawrence's place. Uiagalelei enters Saturday's ACC clash having completed 12-of-19 pass attempts for 102 yards and zero touchdowns this season. The Eagles are 0-9 in their last nine games against Clemson, however Boston College is 5-1 against the spread in its last six games against an ACC opponent.
Kickoff from Memorial Stadium in Clemson, S.C., is at noon ET. The latest Clemson vs. Boston College odds from William Hill list the Tigers as 25-point favorites, which is down seven points since the Lawrence news broke. The over-under for total points expected is set at 58, down from opening at 59.5. Before making any Boston College vs. Clemson picks, check out the college football predictions from the SportsLine Projection Model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of nearly $4,000 for $100 players on its top-rated college football picks against the spread. It is a sizzling 29-19 on top-rated picks through eight weeks of the 2020 college football season, returning nearly $500 in profit already. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Clemson vs. Boston College. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Boston College vs. Clemson:
- Clemson vs. Boston College spread: Clemson -25
- Clemson vs. Boston College over-under: 58 points
- Clemson vs. Boston College money line: Boston College +1200, Clemson -2400
- BC: Is averaging 27.5 points per game
- CLEM: Attempting to improve to 19-2 all-time when ranked No. 1 by The Associated Press
Why Clemson can cover
With Lawrence out of the lineup on Saturday, Dabo Swinney and the Tigers will rely heavily on running back Travis Etienne. The senior running back enters Saturday's ACC clash averaging 6.3 yards per carry this season. He's carried the ball 83 times for 522 yards and eight touchdowns already this season.
Etienne is coming off a sensational performance against the Syracuse Orange last week, finishing with 16 carries for 86 yards and three touchdowns. Now, he'll look to exploit a Boston College defense that's giving up 165.3 yards per game on the ground. Clemson's depth on defense has also been on full display this season as the Tigers are giving up just 13.5 points per game, which ranks 12th in the nation. Last season, Clemson's defense held Boston College to just seven points.
Why Boston College can cover
Eagles quarterback Phil Jurkovec has brought a new dimension to Boston College's offense. Jurkovec has completed 140 of 224 passes (62.5 percent) for 1,671 yards and 12 touchdowns for a rating of 139.3. He has also rushed 53 times for 109 yards (2.1 average) and three TDs. His best game was against Pittsburgh on Oct. 10 in a 31-30 overtime win when he completed 19 of 35 attempts (54.3 percent) for 358 yards and three touchdowns.
Jurkovec's top target has been junior tight end Hunter Long, who has a team-high 38 receptions for 455 yards (12.0 average) and three scores. Long had back-to-back nine-catch games in Weeks 2 and 3 against Texas State and No. 12 North Carolina. Against Texas State, Long had 81 yards receiving and a touchdown. He added 96 yards against the Tar Heels, including a long gain of 31 yards. In three seasons at BC, Long has 70 receptions for 1,067 yards (15.2 average) and seven TDs.
How to make Clemson vs. Boston College picks
SportsLine's model is leaning under on the total. In fact, it says Clemson running backs will be held to just two touchdowns, while Jurkovec will throw for fewer than 175 yards and one touchdown. It has also generated an against-the-spread pick that cashes in over 50 percent of simulations. You can only get the pick at SportsLine.
So who wins Boston College vs. Clemson? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Clemson vs. Boston College spread to back, all from the advanced model that is up nearly $4,000 on its top-rated college football spread picks, and find out.