Trevor Lawrence's absence due to COVID-19 might end up costing him the Heisman Trophy in what could be his final season with the Clemson Tigers. It also played a part in ending fourth-ranked Clemson's regular-season winning streak at 39 games, as it fell at Notre Dame in double overtime last time out. Lawrence will attempt to get the Tigers back on track as he returns for their ACC matchup against the visiting Pittsburgh Panthers on Saturday. Kickoff from Memorial Stadium is scheduled for 3:30 p.m. ET.

Clemson (7-1, 6-1 ACC) is riding a school-record 27-game home winning streak, last losing at Memorial Stadium on Nov. 12, 2016 -- a 43-42 setback against Pittsburgh. The Panthers (5-4, 4-4) have held both of their last two opponents under 20 points after allowing at least 30 in each contest during a four-game losing streak. The Tigers are 24-point favorites in the latest Clemson vs. Pittsburgh odds from William Hill Sportsbook, while the over-under for total points scored is 58. Before making any Pittsburgh vs. Clemson picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It is also a sizzling 44-23 on all top-rated picks through 12 weeks of the 2020 college football season, returning over $1,200 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Pitt. You can visit SportsLine now to see the picks. Here are the college football odds and trends for Pitt vs. Clemson:

  • Clemson vs. Pittsburgh spread: Tigers -24
  • Clemson vs. Pittsburgh over-under: 58 points
  • Clemson vs. Pittsburgh money line: Tigers -2000, Panthers +1000
  • CLEM: The Tigers are 2-7 against the spread in their last nine games
  • PITT: The Panthers are 1-4 ATS in their last five road contests

Why Clemson can cover

Lawrence, who can tie the school record of 32 career wins by a starting quarterback on Saturday, has thrown touchdown passes to nine different players this season -- including five to Amari Rodgers. The senior is the Tigers' top wideout, leading the team in catches (48), receiving yards (720) and TD catches (six). Rodgers posted his second 100-yard performance of 2020 in the Nov. 7 loss at Notre Dame, hauling in eight passes for 134 yards.

Another of Lawrence's top targets is senior wide receiver Cornell Powell, who racked up 161 yards and a TD against the Fighting Irish. Sophomore tight end Davis Allen has caught a scoring pass in four of his last five contests while Travis Etienne is second on the team with 37 receptions and 491 yards. The senior running back has gained 634 yards on 121 carries while running for 10 touchdowns, with nine coming during his current six-game streak.

Why Pittsburgh can cover

The Panthers have posted back-to-back victories following a four-game losing streak, outscoring their opponents 88-31. Kenny Pickett threw for 404 yards and a pair of touchdowns while also running for a score in last Saturday's 47-14 triumph over Virginia Tech. It was the second 400-yard performance of the year for the senior, who leads Pittsburgh with seven rushing TDs and has registered one in six of his seven games in 2020.

Pittsburgh leads the nation with 97 tackles for loss overall and 10.8 per game, while linebacker SirVocea Dennis is third in the country with 13.5 on the season. The Panthers also are the best at getting to the quarterback, as they have registered a nation-best 40 sacks. Defensive lineman Patrick Jones II is tied for second in the country with eight sacks for Pittsburgh, which leads the ACC and ranks fourth in the nation with 12 interceptions.

How to make Clemson vs. Pittsburgh picks

SportsLine's model is leaning under the total. In fact, it says the two teams will combine to score 56 points. It also has generated an against-the-spread pick that cashes in 60 percent of simulations. You can only get the pick at SportsLine.

So who wins Clemson vs. Pittsburgh? And which side of the spread cashes in 60 percent of simulations? Visit SportsLine now to see which side of the Pittsburgh vs. Clemson spread to jump on, all from the advanced model that is up over $3,600 on its top-rated college football spread picks, and find out.