A possible preview of the ACC Championship Game unfolds Saturday when the Pittsburgh Panthers (5-1) host the Clemson Tigers (4-2). Pitt leads the Coastal Division, while Clemson surprisingly sits behind Wake Forest and NC State in the Atlantic Division. Two early-season losses have knocked Clemson out of the College Football Playoff conversation, but a win over the Panthers would be a huge boost for its conference title hopes. 

Kickoff is set for 3:30 p.m. ET. Caesars Sportsbook lists the Panthers as 3.5-point favorites in the latest Clemson vs. Pittsburgh odds. The over-under for total points is set at 47. Before making any Clemson vs. Pittsburgh picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Pitt vs. Clemson. You can head to SportsLine to see its picks. Here are several college football odds for Clemson vs. Pitt:

  • Pittsburgh vs. Clemson spread: Pittsburgh -3.5
  • Pittsburgh vs. Clemson over-under: 47 points
  • Pittsburgh vs. Clemson money line: Pitt -170, Clemson +145
Featured Game | Pittsburgh Panthers vs. Clemson Tigers

What you need to know about Pittsburgh

Kenny Pickett is one of the country's top quarterbacks. He's completed 69.8 percent of his passes for 1,934 yards and has thrown a staggering 21 touchdowns compared to just one INT on the season. He's found the end zone three times on the ground as well.

The Panthers have been great against the spread. They have a 4-1 ATS mark against FBS competition and they cleared the spread last week with 14.5 points to spare at Virginia Tech and by 31 points the prior week against Georgia Tech. Clemson, meanwhile, has yet to cover this season, setting up a potential value spot on Pitt in this matchup. 

What you need to know about Clemson

DJ Uiagalelei just hasn't put up the kind of numbers expected of him when he joined Clemson as the top QB recruit in the country. Following Trevor Lawrence's tenure, the expectation was that he would step right in and add another gear as a mobile passer. Although the Tigers are doing just enough to get wins this year, he's completed just 55 percent of his passes for an underwhelming 5.6 yards per attempt.

Running back Kobe Pace had a nice day last weekend in Clemson's 17-14 win over Syracuse, and carried the ball 14 times for 76 yards and a touchdown. Through six games, Clemson has just the 84th-best rushing offense in the country. The Tigers' defense has still been strong, and only surrenders 113 total rushing yards and 201 passing yards per game on average.

How to make Pittsburgh vs. Clemson picks

The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Pittsburgh vs. Clemson? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks