The No. 10 Clemson Tigers (5-1) will play their first home game of the month when they host the Virginia Cavaliers (4-2) on Saturday afternoon. Clemson opened the season with a blowout loss at then-No. 1 Georgia, but it has kept its College Football Playoff hopes alive with a five-game winning streak. The Tigers are coming off back-to-back road wins against Florida State and Wake Forest, remaining atop the ACC standings. Virginia had its two-game winning streak snapped in a 24-20 loss to Louisville last week.
Kickoff is set for noon ET on Saturday at Memorial Stadium. Clemson is favored by 21 points in the latest Clemson vs. Virginia odds, while the over/under is 57.5 points, per SportsLine consensus. Before entering any Virginia vs. Clemson picks, you'll want to see the college football predictions from the model at SportsLine.
The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 12-5 on all top-rated picks for sports betting over the past three weeks of this season. Anyone who has followed it at sports betting apps has seen strong returns
The model has set its sights on Clemson vs. Virginia. You can head to SportsLine to see its picks. Here are several college football betting lines from sports betting sites for the Virginia vs. Clemson game:
- Clemson vs. Virginia spread: Clemson -21
- Clemson vs. Virginia over/under: 57.5 points
- Clemson vs. Virginia money line: Clemson: -1786, Virginia: +932
- Clemson vs. Virginia picks: See picks here
- Clemson vs. Virginia streaming: FuboTV (Try for free)
Why Clemson can cover
While many people ruled Clemson out following its loss to top-ranked Georgia at the end of August, the Tigers have inserted themselves back into the College Football Playoff conversation with a five-game winning streak. They have won all five of those games by at least 16 points, including a 49-14 win at Wake Forest last week. Junior quarterback Cade Klubnik completed 31 of 41 passes for 309 yards, three touchdowns and zero interceptions in that game, giving him 17 touchdown passes and just one interception since the loss to Georgia.
Senior running back Phil Mafah had 19 carries for 108 yards and two touchdowns in last week's win, averaging 5.7 yards per carry. He has gone over 100 rushing yards in four of his last five games, giving Clemson one of the most explosive offenses in college football. The Tigers have covered the spread in six straight home games and have won their last five games against Virginia. See which team to pick here.
Why Virginia can cover
Virginia has been one of the most undervalued teams in college football since the beginning of last season, covering the spread at an 11-3-1 clip in its last 15 games. The Cavaliers are unbeaten against the spread in their last six road games, winning their first two road games this season. Their latest road victory came in a 43-24 win at Coastal Carolina last month, easily covering the spread as 4-point favorites.
Sophomore quarterback Anthony Colandrea had 131 passing yards and two touchdowns in that win, while junior running back Xavier Brown tallied a whopping 171 rushing yards on just nine carries. The Cavaliers added an outright win over Boston College at the beginning of October before covering the 7.5-point underdog spread in a 24-20 loss to Louisville last week. Colandrea had 279 passing yards and a touchdown while rushing for 84 yards in the loss to the Cardinals. See which team to pick here.
How to make Clemson vs. Virginia picks
The model has simulated Virginia vs. Clemson 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.
So who wins Clemson vs. Virginia, and which side of the spread is hitting well over 50% of the time? Visit SportsLine now to see which side of the Virginia vs. Clemson spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.









