Some of college football's usual powers have stumbled a bit out of the gate in 2021. No. 9 Clemson and No. 10 Ohio State have already been handed a loss. No. 1 Alabama, No. 4 Oklahoma and No. 12 Notre Dame, meanwhile, have all had at least one big scare. The path to the College Football Playoff feels a bit more open this year, and the Week 4 college football odds board at Caesars Sportsbook shows some intriguing matchups.

Notre Dame is a 6.5-point underdog against No. 18 Wisconsin in a noon ET matchup. The latest Week 4 college football spreads also show Clemson at -10 against NC State. Which college football lines have the most value on Saturday? Before locking in any college football bets, be sure to see the top Week 4 college football expert picks, predictions and best bets from Barrett Sallee.

Sallee is a true insider -- a CBS Sports analyst, SiriusXM host, Heisman voter and consistently one of the top CBS Sports experts picking games against the spread -- and his best bets have helped bring in huge returns. He debuted with SportsLine in 2017 and has delivered in a big way on his college football picks

Over the past two-plus years, he is 85-61 in his popular best bets column at SportsLine. Anybody who has been following him is way up.

Now, he has turned his attention to the Week 4 college football odds from Caesars and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks now

Top Week 4 college football expert predictions

One of Sallee's top college football picks for Week 4: Sallee likes Notre Dame to stay within the 6.5-point spread against Wisconsin when the teams meet at Soldier Field in Chicago at noon ET.

A big x-factor in this matchup is Notre Dame quarterback Jack Coan, a transfer from Wisconsin. The Badgers know him well, but Sallee thinks that his knowledge of the Wisconsin defense should serve the Fighting Irish well.

Notre Dame safety Kyle Hamilton is perhaps the most talented player in this matchup, and he should prevent Wisconsin from stretching the field. Sallee sees Note Dame then shutting down Wisconsin's rushing attack and keeping this game at least within the spread.

"I know that Notre Dame has been one of the most disappointing 3-0 teams in the country so far, but it still has plenty of power," Sallee told SportsLine.

Featured Game | Wisconsin Badgers vs. Notre Dame Fighting Irish

How to make Week 4 college football picks 

Sallee has also found two other college football picks he's high on, including a play on another underdog he believes can not only cover, but win outright. You can only see his picks at SportsLine.

What are the best bets for Week 4 of college football? And which underdog do you need to be all over? Visit SportsLine now to see Barrett Sallee's college football best bets, all from one of the top analysts in the nation who has crushed his picks for SportsLine.