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Top-ranked Clemson faces its largest spread against an FBS opponent in history when it hosts Syracuse at noon ET on Saturday. The Tigers are massive 46-point favorites in the latest Week 8 college football odds from William Hill. Five of the past six teams that have been underdogs of 40 points or more in conference play have kept it within the spread, so should you back Syracuse with the points in that ACC matchup?

And which side should you target in your Week 8 college football bets in games with tighter spreads such as Auburn vs. Ole Miss (+3) and No. 9 Cincinnati at No. 16 SMU (-2.5)? Before locking anything in for this weekend's action, be sure to see the top Week 8 college football expert picks, predictions and best bets from Barrett Sallee.

Sallee is a true insider -- a CBS Sports analyst, SiriusXM host, Heisman voter and consistently one of the top CBS Sports experts picking games against the spread -- and his best bets have helped bring in huge returns. He debuted with SportsLine in 2017 and has delivered in a big way, posting a winning record in his weekly college football best bets column since that point. 

He went 59-35-2 (63 percent, plus $2,037) on all his college football picks for SportsLine in 2019, and he also enters Week 8 of the 2020 college football season on a 53-20 streak on his best bets since the start of last year. Anybody who has been following him is way up.

Now, he has turned his attention to the Week 8 college football odds from William Hill and is sharing his top three best bets over at SportsLine. Get his top college football picks now

Top Week 8 college football expert predictions

One of Sallee's top college football picks for Week 8: He likes the Oklahoma Sooners (-6.5) to cover at TCU on Saturday in a noon ET kickoff in Big 12 action. TCU is just 1-2 on the season with an upset win over Texas sandwiched between losses to Iowa State and Kansas State

The Horned Frogs have struggled defensively in the red zone. TCU is giving up a touchdown on almost 67 percent of possessions that reach the red zone, and that's an area Sallee believes the Sooners can exploit.

Sallee expects Oklahoma quarterback Spencer Rattler and the Sooners to build off the confidence they gained from beating Texas in their last game as they get the win and cover on the road.

How to make Week 8 college football picks 

Sallee has also found two other college football picks he's high on, including a strong play on a Big Ten matchup where he believes the wrong side is favored. You can only see his picks at SportsLine.

What are the best bets for Week 8 of college football? And which line is way off? Visit SportsLine now to see Barrett Sallee's college football best bets, all from one of the top analysts in the nation who has crushed his picks for SportsLine.